Pei Jing, Ding Zhaoran, Jiao Cheng, Tao Ying, Yang Huifen, Li Jing
Department of Otolaryngology, Head and Neck Surgery, The Affiliated Jiangning Hospital With Nanjing Medical University, Nanjing, Jiangsu, China.
Department of Otorhinolaryngology Head and Neck Surgery, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu, China.
Front Cell Dev Biol. 2024 Jun 12;12:1417735. doi: 10.3389/fcell.2024.1417735. eCollection 2024.
Basic research on chronic rhinosinusitis (CRS) has advanced significantly in the past two decades, yet a comprehensive understanding of its pathogenic mechanisms remains elusive. Concurrently, there is a growing interest among scientists in exploring the involvement of autophagy in various human diseases, including tumors and inflammatory conditions. While the role of autophagy in asthma has been extensively studied in airway inflammatory diseases, its significance in CRS with or without nasal polyps (NPs), a condition closely linked to asthma pathophysiology, has also garnered attention, albeit with conflicting findings across studies. This review delves into the role of autophagy in CRS, suggesting that modulating autophagy to regulate inflammatory responses could potentially serve as a novel therapeutic target.
在过去二十年中，慢性鼻-鼻窦炎（CRS）的基础研究取得了显著进展，但对其致病机制的全面理解仍然难以捉摸。与此同时，科学家们越来越有兴趣探索自噬在包括肿瘤和炎症性疾病在内的各种人类疾病中的作用。虽然自噬在哮喘等气道炎症性疾病中的作用已得到广泛研究，但它在与哮喘病理生理学密切相关的伴或不伴鼻息肉（NP）的CRS中的意义也受到了关注，尽管各研究结果相互矛盾。本综述深入探讨了自噬在CRS中的作用，表明调节自噬以调控炎症反应可能成为一种新的治疗靶点。
