血管加压素、蛋白质代谢和水的保存。
Vasopressin, protein metabolism, and water conservation.
机构信息
Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
Epigenetics and Stem Cell Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina.
出版信息
Curr Opin Nephrol Hypertens. 2024 Sep 1;33(5):512-517. doi: 10.1097/MNH.0000000000001012. Epub 2024 Jun 27.
PURPOSE OF REVIEW
Highlight the mechanisms through which vasopressin and hypertonic stress regulate protein metabolism.
RECENT FINDINGS
Mammals have an 'aestivation-like' response in which hypertonic stress increases muscle catabolism and urea productionVasopressin can directly regulate ureagenesis in the liver and the kidneyIn humans chronic hypertonic stress is associated with premature aging, diabetes, cardiovascular disease, and premature mortality.
SUMMARY
There is an evolutionarily conserved 'aestivation-like' response in humans in which hypertonic stress results in activation of the vasopressin system, muscle catabolism, and ureagenesis in order to promote water conservation.
目的综述
强调血管加压素和高渗应激调节蛋白质代谢的机制。
最新发现
哺乳动物有一种“夏眠样”反应，其中高渗应激会增加肌肉分解代谢和尿素生成。血管加压素可以直接调节肝脏和肾脏的尿素生成。在人类中，慢性高渗应激与衰老、糖尿病、心血管疾病和过早死亡有关。
总结
人类中存在一种进化保守的“夏眠样”反应，其中高渗应激导致血管加压素系统的激活、肌肉分解代谢和尿素生成，以促进水的保存。
Zotero 插件