Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China; CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing, China.
Academy for Engineering and Technology, Fudan University, Shanghai, China.
Neurobiol Dis. 2024 Sep;199:106581. doi: 10.1016/j.nbd.2024.106581. Epub 2024 Jun 25.
Deep brain stimulation (DBS) targeting the globus pallidus internus (GPi) and subthalamic nucleus (STN) is employed for the treatment of dystonia. Pallidal low-frequency oscillations have been proposed as a pathophysiological marker for dystonia. However, the role of subthalamic oscillations and STN-GPi coupling in relation to dystonia remains unclear.
We aimed to explore oscillatory activities within the STN-GPi circuit and their correlation with the severity of dystonia and efficacy achieved by DBS treatment.
Local field potentials were recorded simultaneously from the STN and GPi from 13 dystonia patients. Spectral power analysis was conducted for selected frequency bands from both nuclei, while power correlation and the weighted phase lag index were used to evaluate power and phase couplings between these two nuclei, respectively. These features were incorporated into generalized linear models to assess their associations with dystonia severity and DBS efficacy.
The results revealed that pallidal theta power, subthalamic beta power and subthalamic-pallidal theta phase coupling and beta power coupling all correlated with clinical severity. The model incorporating all selected features predicts empirical clinical scores and DBS-induced improvements, whereas the model relying solely on pallidal theta power failed to demonstrate significant correlations.
Beyond pallidal theta power, subthalamic beta power, STN-GPi couplings in theta and beta bands, play a crucial role in understanding the pathophysiological mechanism of dystonia and developing optimal strategies for DBS.
深部脑刺激（DBS）靶向苍白球 internus（GPi）和丘脑底核（STN），用于治疗肌张力障碍。苍白球低频振荡被提出作为肌张力障碍的一种病理生理标志物。然而，STN-GPi 回路中的亚丘脑振荡及其与肌张力障碍的关系以及 DBS 治疗的效果仍不清楚。
我们旨在探讨 STN-GPi 回路中的振荡活动及其与肌张力障碍的严重程度和 DBS 治疗效果的相关性。
从 13 名肌张力障碍患者的 STN 和 GPi 同时记录局部场电位。对来自两个核的选定频带进行频谱功率分析，同时使用功率相关性和加权相位滞后指数分别评估这两个核之间的功率和相位耦合。这些特征被纳入广义线性模型，以评估它们与肌张力障碍严重程度和 DBS 疗效的相关性。
结果表明，苍白球θ功率、丘脑底核β功率以及丘脑底核-苍白球θ相位耦合和β功率耦合均与临床严重程度相关。纳入所有选定特征的模型可预测经验临床评分和 DBS 诱导的改善，而仅依赖苍白球θ功率的模型未能显示出显著相关性。
除苍白球θ功率外，丘脑底核β功率、STN-GPi 在θ和β频段的耦合在理解肌张力障碍的病理生理机制和制定 DBS 的最佳策略方面起着至关重要的作用。
