Precision Medicine Laboratory, School of Medical Technology and Engineering, Henan University of Science and Technology, Luoyang, China.
Department of General Surgery, First Affiliated Hospital, College of Clinical Medicine, Henan University of Science and Technology, Luoyang, China.
Mol Cell Endocrinol. 2024 Oct 1;592:112321. doi: 10.1016/j.mce.2024.112321. Epub 2024 Jun 25.
The tricarboxylic acid (TCA) cycle is an essential interface that coordinates cellular metabolism and is as a primary route determining the fate of a variety of fuel sources, including glucose, fatty acid and glutamate. The crosstalk of nutrients replenished TCA cycle regulates breast cancer (BC) progression by changing substrate levels-induced epigenetic alterations, especially the methylation, acetylation, succinylation and lactylation. Long non-coding RNAs (lncRNA) have dual roles in inhibiting or promoting energy reprogramming, and so altering the metabolic flux of fuel sources to the TCA cycle, which may regulate epigenetic modifications at the cellular level of BC. This narrative review discussed the central role of the TCA cycle in interconnecting numerous fuels and the induced epigenetic modifications, and the underlying regulatory mechanisms of lncRNAs in BC.
三羧酸（TCA）循环是一个重要的界面，协调细胞代谢，并作为主要途径决定各种燃料来源的命运，包括葡萄糖、脂肪酸和谷氨酸。营养物质的交叉补充 TCA 循环通过改变底物水平诱导的表观遗传改变来调节乳腺癌（BC）的进展，特别是甲基化、乙酰化、琥珀酰化和乳酰化。长链非编码 RNA（lncRNA）在抑制或促进能量重编程方面具有双重作用，从而改变燃料来源到 TCA 循环的代谢通量，这可能调节 BC 细胞水平的表观遗传修饰。本综述讨论了 TCA 循环在连接多种燃料和诱导的表观遗传修饰中的核心作用，以及 lncRNA 在 BC 中的潜在调节机制。
