Department of Gastroenterology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, P.R. China.
Department of Gastroenterology, The Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563003, P.R. China.
Oncol Rep. 2021 May;45(5). doi: 10.3892/or.2021.8005. Epub 2021 Mar 24.
Metabolism is defined as the biochemical processes that produce or consume energy in living organisms. Otto Warburg suggested that cancer is a metabolic disease, thus metabolic reprogramming is widely considered as an emerging hallmark of cancer cells. Long non‑coding RNAs (lncRNAs), which are defined as transcripts >200 nucleotides with limited protein coding potential, are involved in cancer metabolism. lncRNAs can control pathophysiological processes of cancer by regulating gene expression at epigenetic, transcriptional and post‑transcriptional levels. The process of tumorigenesis is usually accompanied by alterations in metabolic patterns, involving glycolysis, the tricarboxylic acid cycle, mitochondrial oxidative phosphorylation, the pentose phosphate signaling pathway, glutamine metabolism and lipid metabolism, which is also known as metabolic reprogramming. The present review summarized the functions of lncRNAs in cancer metabolism and discussed how the dysregulation of lncRNAs contributed to metabolic reprogramming and tumorigenesis, which may provide novel therapeutic targets for cancer.
代谢被定义为生物体内产生或消耗能量的生化过程。奥托·瓦尔堡（Otto Warburg）提出癌症是一种代谢疾病，因此代谢重编程被广泛认为是癌细胞的一个新兴特征。长链非编码 RNA（lncRNA）被定义为具有有限蛋白编码潜力的转录本＞200 个核苷酸，参与癌症代谢。lncRNA 可以通过在表观遗传、转录和转录后水平上调节基因表达来控制癌症的病理生理过程。肿瘤发生的过程通常伴随着代谢模式的改变，涉及糖酵解、三羧酸循环、线粒体氧化磷酸化、戊糖磷酸信号通路、谷氨酰胺代谢和脂质代谢，这也被称为代谢重编程。本综述总结了 lncRNA 在癌症代谢中的功能，并讨论了 lncRNA 的失调如何导致代谢重编程和肿瘤发生，这可能为癌症提供新的治疗靶点。
