评估耐多药结核病患者的生活质量：一项横断面研究。
Assessing the quality of life in patients with drug-resistant tuberculosis: a cross-sectional study.
机构信息
School of Nursing, Nanjing University of Chinese Medicine, No.138 Xianlin Avenue, Qixia District, Nanjing, Jiangsu Province, P.R. China.
Department of Tuberculosis, The Second Hospital of Nanjing, Affiliated to Nanjing University of Chinese Medicine, No.1 Rehabilitation Road, Tangshan Street, Jiangning District, Nanjing, Jiangsu Province, P.R. China.
出版信息
BMC Pulm Med. 2024 Jun 27;24(1):303. doi: 10.1186/s12890-024-03119-1.
BACKGROUND
This study investigated the current status of the quality of life (QOL) of drug-resistant tuberculosis (DR-TB) patients in Nanjing, China, and analyzed the influencing factors.
METHODS
The survey was conducted among patients with DR-TB who were hospitalized in the tuberculosis department of the Second Hospital of Nanjing (Nanjing Public Health Medical Center) from July 2022 to May 2023. The Chinese version of the World Health Organization Quality of Life (WHOQOL-BREF) questionnaire was used to investigate the QOL levels of patients with DR-TB, and a multiple linear regression model was used to analyze the QOL influencing factors.
RESULTS
A total of 135 patients participated in the study; 69.6% were male, the average age was 46.30 ± 17.98 years, 13.33% had an education level of elementary school or below, and 75.56% were married. The QOL scores were 51.35 ± 17.24, 47.04 ± 20.28, 43.89 ± 17.96, and 35.00 ± 11.57 in the physiological, psychological, social, and environmental domains, respectively. The differences between the four domain scores and the Chinese normative results were statistically significant (P < 0.05). The results of multiple linear regression analysis showed that the factors related to the physiological domain included residence, family per-capita monthly income, payment method, adverse drug reactions (ADRs), and comorbidities; psychological domain correlates included educational level, family per-capita monthly income, course of the disease, and caregivers; social domain correlates included age and comorbidities; and factors related to the environmental domain included age, education level, and comorbidities.
CONCLUSIONS
In Nanjing, China, patients with younger age, higher education level, living in urban areas, high family per-capita monthly income, no adverse drug reactions, no comorbidities, and having caregivers have better quality of life. Future interventions to improve the quality of life of patients with drug-resistant tuberculosis could be tailored to a specific factor.
背景
本研究调查了中国南京耐多药结核病（DR-TB）患者的生活质量（QOL）现状，并分析了影响因素。
方法
本研究于 2022 年 7 月至 2023 年 5 月期间，对在南京市第二医院（南京市公共卫生医疗中心）结核科住院的 DR-TB 患者进行调查。采用世界卫生组织生活质量简表（WHOQOL-BREF）中文版调查 DR-TB 患者的 QOL 水平，并采用多元线性回归模型分析 QOL 的影响因素。
结果
共纳入 135 例患者，其中男 69.6%，平均年龄（46.30±17.98）岁，文化程度小学及以下占 13.33%，已婚占 75.56%。生理、心理、社会和环境领域的 QOL 评分分别为 51.35±17.24、47.04±20.28、43.89±17.96、35.00±11.57，4 个领域评分与中国常模比较，差异均有统计学意义（P<0.05）。多元线性回归分析结果显示，生理领域与居住情况、家庭人均月收入、付费方式、药物不良反应（ADR）和合并症有关；心理领域与文化程度、家庭人均月收入、病程和照顾者有关；社会领域与年龄和合并症有关；环境领域与年龄、文化程度和合并症有关。
结论
在南京，年龄较小、文化程度较高、居住在城镇、家庭人均月收入较高、无药物不良反应、无合并症、有照顾者的患者生活质量较好。未来改善耐多药结核病患者生活质量的干预措施可以针对特定因素进行定制。
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