隔膜起始网络中温度敏感突变体Spg1 GTP酶的特性分析。
Characterization of temperature-sensitive mutants in the septation initiation network Spg1 GTPase.
作者信息
Fletcher Anna Bowman, Turner Lesley A, Ren Liping, Willet Alaina H, Gould Kathleen L
机构信息
Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, US.
The Harpeth Hall School, Nashville, TN, US.
出版信息
MicroPubl Biol. 2024 Jun 12;2024. doi: 10.17912/micropub.biology.001193. eCollection 2024.
The GTPase, Spg1 , activates the septation initiation network (SIN) protein kinase cascade to trigger septation. In the absence of functional Spg1 , cells fail cytokinesis and become multinucleate. In this study, we characterize a set of temperature-sensitive alleles isolated in the 1990s. We identify the mutations within each new and previously characterized allele, characterize the extent of relative growth defects, and assess their interaction with other SIN alleles.
GTP酶Spg1激活隔膜起始网络（SIN）蛋白激酶级联反应以触发隔膜形成。在缺乏功能性Spg1的情况下，细胞无法进行胞质分裂并变成多核细胞。在本研究中，我们对20世纪90年代分离出的一组温度敏感型等位基因进行了表征。我们确定了每个新的和先前已表征的等位基因中的突变，表征了相对生长缺陷的程度，并评估了它们与其他SIN等位基因的相互作用。
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