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2013 - 2019年波兰肿瘤综合治疗方案实施对直肠癌治疗的影响——多中心研究

The impact of oncological package implementation on the treatment of rectal cancer in years 2013-2019 in Poland - multicenter study.

作者信息

Krzeszowiak Jerzy, Pach Radosław, Richter Piotr, Lorenc Zbigniew, Rutkowski Andrzej, Ochwat Kajetan, Zegarski Wojciech, Frączek Mariusz, Szczepanik Antoni

机构信息

Jagiellonian University Medical College, Krakow, Poland.

1st Department of Surgery, Jagiellonian University, Krakow, Poland.

出版信息

Pol Przegl Chir. 2024 Feb 8;96(3):18-25. doi: 10.5604/01.3001.0054.2680.

DOI:10.5604/01.3001.0054.2680
PMID:38940243
Abstract

<b><br>Introduction:</b> In 2015, in Poland, the oncological package (OP) was established. This law constituted a fast track of oncological diagnosis and treatment and obligatory multidisciplinary team meetings (MDT).</br> <b><br>Aim:</b> The aim of this study was to analyze the impact of OP on rectal cancer treatment.</br> <b><br>Methods:</b> The study was a multicenter, retrospective analysis of data collected from five centers. It included clinical data of patients operated on due to rectal cancer between 2013 and 2019. For most analyses, patients were categorized into three groups: 2013-2014 - before OP (A), 2015-2016 - early development of OP (B), 2017-2019 - further OP functioning (C).</br> <b><br>Results:</b> A total of 1418 patients were included. In all time intervals, the majority of operations performed were anterior resections. There was a significantly lower local tumor stage (T) observed in subsequent time intervals, while there were no significant differences for N and M. In period C, the median of resected nodes was significantly higher than in previous periods. Four of the centers showed an increasing tendency in the use of preoperative radiotherapy. The study indicated a significant increase in the use of short-course radiotherapy (SCRT) and a decrease in the number of patients who did not receive any form of preoperative therapy in subsequent periods. In the group that should receive radiotherapy (T3/4 or N+ and M0), the use of SCRT was also significantly increasing.</br> <b><br>Conclusions:</b> In the whole cohort, there was a significant increase in the use of preoperative radiotherapy and a decrease in the T stage, changing with the development of OP. Nevertheless, this relation is indirect and more data should be gathered for further conclusions.</br&gt.

摘要

引言:2015年,波兰制定了肿瘤治疗套餐(OP)。该法律构成了肿瘤诊断和治疗的快速通道以及强制性多学科团队会议(MDT)。

目的:本研究的目的是分析肿瘤治疗套餐对直肠癌治疗的影响。

方法:该研究是一项多中心回顾性分析,收集了来自五个中心的数据。它包括2013年至2019年因直肠癌接受手术的患者的临床数据。对于大多数分析,患者被分为三组:2013 - 2014年——肿瘤治疗套餐实施前(A组),2015 - 2016年——肿瘤治疗套餐早期发展阶段(B组),2017 - 2019年——肿瘤治疗套餐进一步运行阶段(C组)。

结果:共纳入1418例患者。在所有时间段内,进行的大多数手术都是前切除术。在随后的时间段内观察到局部肿瘤分期(T)显著降低,而N和M分期无显著差异。在C组中,切除淋巴结的中位数显著高于先前阶段。四个中心术前放疗的使用呈增加趋势。研究表明,短程放疗(SCRT)的使用显著增加,且在随后各阶段未接受任何形式术前治疗的患者数量减少。在应接受放疗的组(T3/4或N+且M0)中,短程放疗的使用也显著增加。

结论:在整个队列中,随着肿瘤治疗套餐的发展,术前放疗的使用显著增加,T分期降低。然而,这种关系是间接的,需要收集更多数据以得出进一步结论。

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