Huang Haowei, Tang Jinrui, Dang Kunrong, Tang Jiayue, Li Enxian, Fan Liming, Ye Min, Wu Guoxing, Su Fawu
State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, School of Plant Protection, Yunnan Agricultural University, Kunming, China.
Nat Prod Res. 2024 Jun 28:1-6. doi: 10.1080/14786419.2024.2371994.
A series of bis(indolyl)-hydrazide-hydrazone derivatives were synthesised, and their structures were characterised using H-NMR and HRMS. The antifungal activity of the prepared compounds was evaluated against Cav., Penz., Pers.: Fr. and Kühn using the mycelial growth rate method. The preliminary bioassays revealed that most of the synthesised compounds exhibited antifungal activity against the four tested fungi and displayed a remarkable inhibitory effect on the mycelium growth of . In particular, compounds 3b, 3c, and 3k demonstrated significant antifungal activity against , with EC values of 26.42, 20.74, and 22.41 μM, respectively, outperforming the positive control shenqinmycin (47.18 μM) and carvacrol (49.13 μM).
合成了一系列双（吲哚基）-酰肼腙衍生物，并使用氢核磁共振（H-NMR）和高分辨质谱（HRMS）对其结构进行了表征。采用菌丝生长速率法，对所制备化合物针对辣椒疫霉（Phytophthora capsici Leonian）、稻瘟病菌（Magnaporthe oryzae (T.T. Hebert) Barr）、核盘菌（Sclerotinia sclerotiorum (Lib.) de Bary）和禾谷镰刀菌（Fusarium graminearum Schwabe）的抗真菌活性进行了评估。初步生物测定表明，大多数合成化合物对四种受试真菌均表现出抗真菌活性，并对稻瘟病菌的菌丝生长显示出显著的抑制作用。特别是，化合物3b、3c和3k对稻瘟病菌表现出显著的抗真菌活性，其半数效应浓度（EC）值分别为26.42、20.74和22.41μM，优于阳性对照申嗪霉素（47.18μM）和香芹酚（49.13μM）。
