银屑病与睡眠障碍:一项基于美国国家健康与营养检查调查(NHANES)数据库的人群研究。

Psoriasis and Sleep Disturbance: A US Population-Based Study Using the NHANES Database.

作者信息

Smith Payton, Jin Joy Q, Spencer Riley K, Elhage Kareem G, Johnson Chandler E, Haran Kathryn, Kranyak Allison, Davis Mitchell S, Hakimi Marwa, Prather Aric A, Stone Katie L, Liao Wilson, Bhutani Tina

机构信息

Department of Dermatology, University of California at San Francisco, 2340 Sutter St., Box 0808, Floor 04, Room N426, San Francisco, CA, 94115, USA.

School of Medicine, University of California at San Francisco, San Francisco, CA, USA.

出版信息

Dermatol Ther (Heidelb). 2024 Aug;14(8):2277-2283. doi: 10.1007/s13555-024-01211-2. Epub 2024 Jun 28.

Abstract

INTRODUCTION

Psoriasis, a chronic inflammatory skin condition, affects approximately 3.0% of the US population, with patients often experiencing significant sleep disturbances. These disturbances include a higher prevalence of conditions such as obstructive sleep apnea, restless leg syndrome, and insomnia. Given the additional risks for cardiovascular disease, metabolic disorders, and depression linked to both poor sleep and psoriasis, addressing sleep issues in this patient group is critical.

METHODS

The study utilized National Health and Nutrition Examination Survey (NHANES) data, focusing on individuals aged ≥ 20 years who provided information on psoriasis status and sleep. Multistage stratified survey methodology was applied, with multivariable logistic regression models used to examine the association between psoriasis and sleep issues, adjusting for factors such as age, gender, and health history.

RESULTS

Psoriasis diagnosis was significantly associated with trouble sleeping (adjusted odds ratio [aOR] 1.88; 95% confidence interval [CI] 1.44-2.45). There was no significant association between psoriasis and sleep quantity. Older age, female gender, and a history of sleep disorders were predictors of trouble sleeping among psoriasis patients.

CONCLUSIONS

Psoriasis is significantly associated with sleep disturbances, independent of sleep duration. This underscores the need for clinical screening focusing on sleep quality rather than quantity in psoriasis patients to effectively identify and treat sleep-related comorbidities. Further research using objective sleep measures is warranted to guide clinical management and improve patient quality of life.

摘要

引言

银屑病是一种慢性炎症性皮肤病,影响着约3.0%的美国人口,患者常常经历严重的睡眠障碍。这些障碍包括阻塞性睡眠呼吸暂停、不宁腿综合征和失眠等疾病的较高患病率。鉴于睡眠不佳和银屑病都与心血管疾病、代谢紊乱及抑郁症的额外风险相关,解决该患者群体的睡眠问题至关重要。

方法

该研究利用了国家健康与营养检查调查(NHANES)的数据,重点关注年龄≥20岁且提供了银屑病状况和睡眠信息的个体。采用多阶段分层调查方法,使用多变量逻辑回归模型来检验银屑病与睡眠问题之间的关联,并对年龄、性别和健康史等因素进行了调整。

结果

银屑病诊断与睡眠困难显著相关(调整后的优势比[aOR]为1.88;95%置信区间[CI]为1.44 - 2.45)。银屑病与睡眠时长之间无显著关联。年龄较大、女性以及有睡眠障碍病史是银屑病患者睡眠困难的预测因素。

结论

银屑病与睡眠障碍显著相关,与睡眠时间无关。这突出了在银屑病患者中进行临床筛查时应关注睡眠质量而非时长的必要性,以便有效识别和治疗与睡眠相关的合并症。有必要进一步开展使用客观睡眠测量方法的研究,以指导临床管理并改善患者生活质量。

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