Institute of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, Gansu, People's Republic of China; Institute of Anatomy and Histology & Embryology, Neuroscience, School of Basic Medical Sciences, Lanzhou University, Lanzhou, Gansu, People's Republic of China.
Institute of Anatomy and Histology & Embryology, Neuroscience, School of Basic Medical Sciences, Lanzhou University, Lanzhou, Gansu, People's Republic of China.
Brain Behav Immun. 2024 Aug;120:499-512. doi: 10.1016/j.bbi.2024.06.026. Epub 2024 Jun 27.
The gut microbiota and neurological development of neonatal mice are susceptible to environmental factors that may lead to altered behavior into adulthood. However, the role that changed gut microbiota and neurodevelopment early in life play in this needs to be clarified. In this study, by modeling early-life environmental changes by cross-fostering BALB/c mice, we revealed the effects of the environment during the critical period of postnatal development on adult social behavior and their relationship with the gut microbiota and the nervous system. The neural projections exist between the ascending colon and oxytocin neurons in the paraventricular nuclei (PVN), peripheral oxytocin levels and PVN neuron numbers decreased after cross-fostering, and sex-specific alteration in gut microbiota and its metabolites may be involved in social impairments and immune imbalances brought by cross-fostering via the gut-brain axis. Our findings also suggest that social cognitive impairment may result from a combination of PVN oxytocinergic neurons, gut microbiota, and metabolites.
新生小鼠的肠道微生物群和神经发育容易受到环境因素的影响，这些因素可能导致成年后的行为改变。然而，需要阐明早期生活中肠道微生物群和神经发育的变化在这方面所起的作用。在这项研究中，通过对 BALB/c 小鼠进行交叉寄养来模拟早期生活环境的变化，我们揭示了出生后发育关键期环境对成年社交行为的影响，以及它们与肠道微生物群和神经系统的关系。升结肠和室旁核(PVN)中的催产素神经元之间存在神经投射，交叉寄养后外周催产素水平和 PVN 神经元数量下降，而肠道微生物群及其代谢物的性别特异性改变可能通过肠道-大脑轴参与了交叉寄养引起的社交障碍和免疫失衡。我们的研究结果还表明，社交认知障碍可能是 PVN 催产素能神经元、肠道微生物群和代谢物共同作用的结果。
