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加纳中部地区医院-社区糖尿病管理干预的影响:一项回顾性研究。

Impact of hospital-community diabetes management intervention in Central Region, Ghana: A retrospective study.

机构信息

School of Public Health, University for Development Studies, Tamale, Ghana.

School of Biomedical and Allied Health Sciences, College of Health Sciences, University of Ghana, Ghana.

出版信息

Diabetes Res Clin Pract. 2024 Jul;213:111762. doi: 10.1016/j.diabres.2024.111762. Epub 2024 Jun 28.

DOI:10.1016/j.diabres.2024.111762
PMID:38944249
Abstract

OBJECTIVE

Effective diabetes management remains suboptimal in low-resourced countries including Ghana. We determined the effectiveness of hospital-community link diabetes management intervention on glycaemic control and other outcomes.

METHODS

A retrospective study design, using secondary data from the Ghana-Netherlands for Health Foundation diabetes programme. The z-test was used for proportions, to compare parameters between baseline (2017) and endpoint (2022). The Friedman test was used to assess changes in blood glucose levels, and the multivariable Logistic regression to identify factors associated with blood glucose control.

RESULTS

Analyses of 251 clinical records showed decline in median blood glucose levels across six years from 8.8 mmol/L (7.2-12.9) in 2017 to 6.5 mmol/L (5.7-7.2) (p = 0.001) in 2022, recording 43 % increase in patients attaining glycaemic control in 2022 (p = 0.001). The Friedman test showed significant reduction in glucose levels (χ = 319.2, p = 0.001), with an effect size of 0.25 using the Kendall test. The logistic regression analyses revealed that patients on metformin and Glibenclamide combination were more likely to achieve glycaemic control than those on metformin monotherapy (adjusted OR = 7.30, 95 % CI 2.31-23.01, p = 0.001).

CONCLUSION

The intervention achieved significant reduction in blood glucose levels. Patients with diabetes benefit from the hospital-community link diabetes management intervention regarding glycaemic control.

摘要

目的

在加纳等资源有限的国家,有效的糖尿病管理仍然不尽如人意。我们旨在评估医院-社区链接式糖尿病管理干预在血糖控制和其他结局方面的效果。

方法

本研究采用回顾性设计,使用加纳-荷兰卫生基金会糖尿病项目的二级数据。使用 z 检验比较基线(2017 年)和终点(2022 年)的参数。采用 Friedman 检验评估血糖水平的变化,采用多变量逻辑回归分析确定与血糖控制相关的因素。

结果

对 251 份临床记录的分析显示,六年期间患者的平均血糖水平从 2017 年的 8.8mmol/L(7.2-12.9)下降到 2022 年的 6.5mmol/L(5.7-7.2)(p=0.001),2022 年达到血糖控制的患者比例增加了 43%(p=0.001)。Friedman 检验显示血糖水平显著降低(χ=319.2,p=0.001),Kendall 检验的效应量为 0.25。逻辑回归分析显示,与使用二甲双胍单药治疗的患者相比,使用二甲双胍和格列本脲联合治疗的患者更有可能达到血糖控制(调整后的 OR=7.30,95%CI 2.31-23.01,p=0.001)。

结论

该干预措施显著降低了血糖水平。糖尿病患者从医院-社区链接式糖尿病管理干预中获益,改善了血糖控制。

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