Turner S M, Jacob R G, Beidel D C, Himmelhoch J
J Clin Psychopharmacol. 1985 Aug;5(4):207-12.
Fluoxetine hydrochloride, a new antidepressant, was administered to 10 obsessive-compulsive patients, and the effects of treatment were examined in a single-blind placebo design. The effects of fluoxetine were examined with respect to depressive symptomatology and obsessions and compulsions per se. The results suggest that fluoxetine affected depressive symptoms but also had an effect on self-reported measures of obsessions and ritualistic behavior. Results are discussed in terms of improvement in obsessive-compulsive disorder, the relation of improvement to initial levels of depression, and patients' ability to tolerate the drug.
新型抗抑郁药盐酸氟西汀应用于10例强迫症患者，并采用单盲安慰剂设计对治疗效果进行了研究。从抑郁症状学以及强迫观念和强迫行为本身方面对氟西汀的疗效进行了考察。结果表明，氟西汀不仅影响抑郁症状，而且对自我报告的强迫观念和仪式行为测量指标也有作用。从强迫症的改善情况、改善与初始抑郁水平的关系以及患者对药物的耐受能力等方面对结果进行了讨论。
