Department of Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur 208016, India.
Trends Endocrinol Metab. 2024 Sep;35(9):761-762. doi: 10.1016/j.tem.2024.06.012. Epub 2024 Jun 29.
In a recent article, Leeson-Payne et al. demonstrate that GPR75 knock-out in mice results in lower body fat and reduced hepatic lipid accumulation, with an increase in physical activity and energy expenditure. Loss-of-function (LoF) GPR75 variants in the UK Biobank (UKBB) are associated with reduced liver steatosis, suggesting potential therapeutic implications in metabolic dysfunction-associated steatotic liver disease (MASLD).
在最近的一篇文章中，Leeson-Payne 等人表明，敲除小鼠的 GPR75 会导致体脂肪减少和肝脂质蓄积减少，同时增加身体活动和能量消耗。英国生物库（UKBB）中 GPR75 失活（LoF）变异与肝脂肪变性减少有关，这表明在代谢功能障碍相关脂肪性肝病（MASLD）中具有潜在的治疗意义。
