Ravanelli Sonia, Park Ji Young Cecilia, Wicky Chantal, Ewald Collin Y, von Meyenn Ferdinand
Laboratory of Nutrition and Metabolic Epigenetics, Institute for Food, Nutrition and Health, Department of Health Sciences and Technology, ETH Zurich, Switzerland.
Laboratory of Extracellular Matrix Regeneration, Institute of Translational Medicine, Department of Health Sciences and Technology, ETH Zurich, Switzerland.
MicroPubl Biol. 2024 Jun 13;2024. doi: 10.17912/micropub.biology.001222. eCollection 2024.
The intersection of metabolic processes and epigenetic regulation during embryogenesis is crucial yet not fully understood. Through a candidate RNAi screen in , we identified metabolic enzymes ALDO-2 and PDHB-1 as potential epigenetic regulators. Mild alteration of the chromatin remodeler LET-418 /Mi2 activity rescues embryonic lethality induced by suppressing or suggesting a critical role for glucose and pyruvate metabolism in chromatin remodeling during embryogenesis. Given the conservation of central metabolic pathways and chromatin modifiers across species, our findings lay the foundation for future mechanistic investigations into the interplay between epigenetics and metabolism during development and upon disease.
胚胎发育过程中代谢过程与表观遗传调控的交叉至关重要，但尚未完全了解。通过在……中进行的候选RNAi筛选，我们确定代谢酶ALDO-2和PDHB-1为潜在的表观遗传调控因子。染色质重塑因子LET-418 / Mi2活性的轻微改变可挽救因抑制……或……而诱导的胚胎致死率，这表明葡萄糖和丙酮酸代谢在胚胎发育过程中的染色质重塑中起关键作用。鉴于跨物种的中心代谢途径和染色质修饰因子具有保守性，我们的研究结果为未来对发育过程中以及疾病发生时表观遗传学与代谢之间相互作用的机制研究奠定了基础。
