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弥漫性牙龈肥大性卡波西肉瘤作为HIV感染的初始表现。

Diffuse gingival hypertrophied Kaposi sarcoma as an initial presentation of HIV Infection.

作者信息

Abose Abinet Meno, Amare Tibebu, Daniel Mierafe, Gebeyehu Anteneh

机构信息

Department of Internal Medicine, School of Medicine, Dilla University, Dilla, Ethiopia.

Department of Pathology, School of Medicine, Wolayita Sodo University, Sodo, Ethiopia.

出版信息

IDCases. 2024 Jun 1;36:e02003. doi: 10.1016/j.idcr.2024.e02003. eCollection 2024.

Abstract

Kaposi sarcoma is an indolent angio-proliferative spindle- cell tumor derived from endothelial and immune cells infected with Human herpes virus type 8(HHV-8). In the era of highly active antiretroviral (HAART), Kaposi sarcoma is a rare form of initial presentation of HIV infection [1]. The author presents a case of diffuse gingival hypertrophied Kaposi sarcoma in 18-year-old male newly diagnosed RVI patient. After confirming the diagnosis patient started on HAART and mouth care. Surgical excision is the first line of treatment with HAART, since this patient has low CD4 count of 30 cells/mm3 which will complicate the surgery. So, we are waiting for CD4 count to increase above 200 cells/mm3 to undergo surgical excision. The case is representative of HIV complexity and aimed to bring awareness of unusual presentation of HIV.This case also reminds us how important early initiation of HAART is.

摘要

卡波西肉瘤是一种生长缓慢的血管增殖性梭形细胞肿瘤,由感染了人类疱疹病毒8型(HHV-8)的内皮细胞和免疫细胞衍生而来。在高效抗逆转录病毒治疗(HAART)时代,卡波西肉瘤是HIV感染初始表现的一种罕见形式[1]。作者报告了一例18岁新诊断为RVI的男性患者出现弥漫性牙龈肥大性卡波西肉瘤的病例。确诊后,患者开始接受HAART治疗和口腔护理。手术切除是HAART治疗的一线方案,由于该患者的CD4细胞计数较低,为30个细胞/mm3,这会使手术复杂化。因此,我们正在等待CD4细胞计数增加到200个细胞/mm3以上再进行手术切除。该病例代表了HIV的复杂性,旨在提高对HIV异常表现的认识。这个病例也提醒我们早期开始HAART治疗有多重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ef2/11214287/2b8edff86e9c/gr1.jpg

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