Abou Hamdan Douaa, Hayek Ghadir, Abi Hanna Pierre, Saliba Michelle, Chehade Issam, Youssef Rozan, Assi Farah
Infectious Diseases, Lebanese University Faculty of Medical Sciences, Beirut, LBN.
Infectious Disease, Lebanese University Faculty of Medical Sciences, Beirut, LBN.
Cureus. 2024 Jul 19;16(7):e64938. doi: 10.7759/cureus.64938. eCollection 2024 Jul.
Kaposi sarcoma is a neoplasm caused by human herpes virus 8 (HHV-8) that commonly presents as subcutaneous lesions but can also involve visceral organs such as the gastrointestinal and pulmonary systems. Diagnosis is achieved through histopathological analysis of cutaneous lesions or lymph nodes. In this study, we report two patients, recently diagnosed with HIV, who were later found to have cutaneous and visceral (pleural) Kaposi sarcoma. In both cases, the patients presented with dyspnea accompanied by cutaneous lesions and bilateral pleural effusion. Unfortunately, the first patient did not survive long enough for treatment initiation. The second patient, however, demonstrated a favorable response to a treatment regimen comprising highly active antiretroviral therapy (HAART) and liposomal doxorubicin.
卡波西肉瘤是一种由人类疱疹病毒8型（HHV-8）引起的肿瘤，通常表现为皮下病变，但也可累及内脏器官，如胃肠道和肺部系统。通过对皮肤病变或淋巴结进行组织病理学分析来实现诊断。在本研究中，我们报告了两名最近被诊断为艾滋病病毒（HIV）感染的患者，后来发现他们患有皮肤和内脏（胸膜）卡波西肉瘤。在这两例病例中，患者均出现呼吸困难，并伴有皮肤病变和双侧胸腔积液。不幸的是，第一名患者存活时间不足，未能开始治疗。然而，第二名患者对包含高效抗逆转录病毒疗法（HAART）和脂质体阿霉素的治疗方案表现出良好反应。
