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伪装成神经系统疾病的胰腺胰岛素瘤:一种罕见肿瘤的诊断与治疗

Pancreatic Insulinoma Masquerading as Neurological Disease: Diagnosis and Treatment of a Rare Tumor.

作者信息

Arowolo Seun A, Khan Muzamil, Hamid Eaman, Ahmed Nusiba, Shabbo Eithar, Nasir Hira

机构信息

Internal Medicine, Obafemi Awolowo University, Ife, NGA.

Internal Medicine, George Washington University School of Medicine and Health Sciences, Washington D.C., USA.

出版信息

Cureus. 2024 May 30;16(5):e61378. doi: 10.7759/cureus.61378. eCollection 2024 May.

Abstract

Insulinomas are rare functional pancreatic neuroendocrine tumors that typically manifest with classic hypoglycemic symptoms, such as diaphoresis, palpitations, and tremors. Although infrequent, neuroglycopenic symptoms associated with insulinomas have been reported, often leading to delayed diagnoses. Here, we present the case of a 31-year-old male with pancreatic insulinoma who experienced recurrent episodes of seizures and confusion preceded by diaphoresis, tremors, and palpitations. During these episodes, he was found to be hypoglycemic. Comprehensive evaluations, including brain and abdominal imaging, as well as biochemical and serological testing, were conducted. The findings confirmed a diagnosis of pancreatic insulinoma. The patient underwent surgical resection of the tumor, and a biopsy confirmed the insulinoma diagnosis. He remained asymptomatic during subsequent follow-ups.

摘要

胰岛素瘤是罕见的功能性胰腺神经内分泌肿瘤,通常表现为典型的低血糖症状,如多汗、心悸和震颤。虽然不常见,但与胰岛素瘤相关的神经低血糖症状已有报道,常常导致诊断延迟。在此,我们报告一例31岁男性胰腺胰岛素瘤患者,该患者在多汗、震颤和心悸之后反复出现癫痫发作和意识模糊。在这些发作期间,发现他血糖过低。进行了包括脑部和腹部成像以及生化和血清学检测在内的全面评估。检查结果证实诊断为胰腺胰岛素瘤。患者接受了肿瘤手术切除,活检证实了胰岛素瘤的诊断。在随后的随访中他一直无症状。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2033/11214572/a5d63e83fd58/cureus-0016-00000061378-i01.jpg

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