吡贝地尔对产后妇女机械性排空乳房所致催乳素释放的抑制作用。

Piribedil inhibition of prolactin release induced by mechanical breast emptying in puerperal women.

作者信息

Alagna S, Lodico G, Devilla L, Masala A, Delitala G, Rovasio P P, Stoppelli I

出版信息

Clin Endocrinol (Oxf). 1979 Sep;11(3):301-5. doi: 10.1111/j.1365-2265.1979.tb03078.x.

DOI:10.1111/j.1365-2265.1979.tb03078.x

Abstract

The effects of a 5 day course of Piribedil, a dopaminergic agonist, on prolactin release evoked by mechanical breast emptying in puerperal women, was investigated. A daily dose of 75 mg. caused a significant decrease in the prolactin response to mechanical breast stimulation. Piribedil also proved clinically useful in inhibiting lactation. The role of dopaminergic mechanisms in the regulation of prolactin release induced by mechanical breast emptying are discussed.

摘要

研究了多巴胺能激动剂吡贝地尔5天疗程对产后妇女机械性排空乳房引起的催乳素释放的影响。每日剂量75毫克可使催乳素对机械性乳房刺激的反应显著降低。吡贝地尔在抑制泌乳方面也被证明具有临床实用性。文中讨论了多巴胺能机制在机械性排空乳房诱导的催乳素释放调节中的作用。