Li Jia-Rui, Xiang Ze, Li Shu-Hui, Li Chen-Xi, Yan Hong, Wu Jian
School of Medicine, Zhejiang University, Hangzhou 310058, Zhejiang Province, China.
Laboratory Medicine Center, The Second Affiliated Hospital of Nanjing Medical University, Nanjing 210011, Jiangsu Province, China.
World J Exp Med. 2024 Jun 20;14(2):90481. doi: 10.5493/wjem.v14.i2.90481.
Hepatitis E virus (HEV), responsible for widespread viral hepatitis, infects approximately 2.3 billion individuals globally, with a significant mortality burden in Asia. The virus, primarily transmitted through contaminated water and undercooked meat, is often underdiagnosed, particularly in immunocompromised patients. Current HEV treatments, while effective, are limited by adverse effects, necessitating research into safer alternatives. Moreover, HEV's extrahepatic manifestations, impacting the nervous and renal systems, remain poorly understood. This study underscores the imperative for enhanced HEV research, improved diagnostic methods, and more effective treatments, coupled with increased public health awareness and preventive strategies.
戊型肝炎病毒（HEV）引发广泛的病毒性肝炎，全球约有23亿人受到感染，在亚洲造成了沉重的死亡负担。该病毒主要通过受污染的水和未煮熟的肉类传播，常常未得到诊断，尤其是在免疫功能低下的患者中。目前的戊型肝炎治疗方法虽然有效，但受到副作用的限制，因此有必要研究更安全的替代方法。此外，戊型肝炎的肝外表现会影响神经和肾脏系统，目前仍知之甚少。这项研究强调了加强戊型肝炎研究、改进诊断方法和更有效治疗的紧迫性，同时提高公众健康意识和预防策略。
