Xu Min, Tian Li-Li, Li Xiao-Liu, Bao Cheng, Zhang Hai-Wei, Chen Hong-Wei
Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, Clinical College of Nanjing University of Chinese Medicine, Nanjing 210008, Jiangsu Province, China.
School of Life Science, Nanjing Normal University, Nanjing 210023, Jiangsu Province, China.
World J Exp Med. 2024 Jun 20;14(2):88867. doi: 10.5493/wjem.v14.i2.88867.
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease in which multiple organs are damaged that prevails in fertile women. Currently, glucocorticoids and immunosuppressants are widely used to treat SLE patients. However, ovarian dysfunction occurs following the use of these drugs in women with SLE. Here, we summarize recent progress in terms of understanding ovarian injury, the effects of drug application and strategies to improve ovarian function in women with SLE. This review could be helpful to precisely cure SLE in women desiring to have offspring.
系统性红斑狼疮（SLE）是一种慢性自身免疫性疾病，多发于育龄女性，可导致多器官受损。目前，糖皮质激素和免疫抑制剂被广泛用于治疗SLE患者。然而，SLE女性患者使用这些药物后会出现卵巢功能障碍。在此，我们总结了在理解SLE女性卵巢损伤、药物应用效果以及改善卵巢功能策略方面的最新进展。这篇综述可能有助于精准治疗有生育意愿的SLE女性患者。
