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冠状动脉搭桥手术的地位:一项评估。

The place of coronary artery bypass surgery: an appraisal.

作者信息

Heller R F, Leeder S R

出版信息

Med J Aust. 1985 Jul 22;143(2):70-2. doi: 10.5694/j.1326-5377.1985.tb122804.x.

Abstract

The enthusiasm for performing coronary artery bypass graft (CABG) surgery in Australia is increasing. The results of a number of careful trials which have compared surgical with medical treatment have now appeared. While there is agreement on both the increased survival provided by CABG surgery in those with left main coronary artery stenosis and the relief of symptoms in patients in whom medical therapy has failed to control severe angina, there is debate about the value of surgery in other types of disease. With improvements in medical therapy, the most recent trials have failed to show a significant overall survival benefit from surgery, although it is generally considered that surgery can relieve angina and that, in at least some groups of persons with stenosis of all three main coronary vessels (triple-vessel disease), surgery may prolong life. Alternative methods of prolonging survival among people with ischaemic heart disease include the reduction of risk factors (such as hypertension, raised blood cholesterol levels and cigarette smoking), as well as treating patients with beta-blocking agents after a myocardial infarction. We suggest it is likely that a combination of these approaches could be more effective in terms of lives saved than is CABG and may be less expensive. The current expansion of CABG surgery in Australia should be viewed in this light.

摘要

在澳大利亚,开展冠状动脉旁路移植术(CABG)手术的热情日益高涨。现在已有多项对比手术治疗与药物治疗的严谨试验结果公布。虽然对于CABG手术能提高左主干冠状动脉狭窄患者的生存率以及缓解药物治疗无法控制严重心绞痛患者的症状这两点已达成共识,但对于手术在其他类型疾病中的价值仍存在争议。随着药物治疗的改进,最近的试验未能显示出手术能带来显著的总体生存获益,尽管人们普遍认为手术可以缓解心绞痛,并且至少在一些三支主要冠状动脉均有狭窄(三支血管病变)的患者群体中,手术可能会延长生命。在缺血性心脏病患者中延长生存期的其他方法包括降低危险因素(如高血压、血液胆固醇水平升高和吸烟),以及在心肌梗死后用β受体阻滞剂治疗患者。我们认为,相较于CABG手术,这些方法的组合在挽救生命方面可能更有效,而且成本可能更低。澳大利亚目前CABG手术的扩张应从这一角度来看待。

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