Lieberthal W, Bernard D B, Donohoe J F, Stilmant M M, Couser W G
Clin Nephrol. 1979 Nov;12(5):222-8.
A patient with membranous nephropathy (MN) received a renal allograft from his brother. The allograft functioned immediately but nephrotic range proteinuria developed seven days after transplantation in the absence of any signs of rejection. Renal function deteriorated five weeks after transplantation due to ureteric obstruction. Nephrostomy drainage resulted in the return of renal function to normal and demonstrated that the allograft was the source of the nephrotic range proteinuria. An open renal biopsy of the allograft performed at the same time revealed the presence of recurrent MN. The recipient was investigated in an attempt to identify possible humoral immune mechanisms that may explain this very rapid recurrence of MN.
一名膜性肾病（MN）患者接受了来自其兄弟的肾移植。移植肾立即开始发挥功能，但在移植后七天出现了肾病范围的蛋白尿，且无任何排斥迹象。移植后五周，由于输尿管梗阻，肾功能恶化。肾造瘘引流使肾功能恢复正常，并表明移植肾是肾病范围蛋白尿的来源。同时对移植肾进行的开放性肾活检显示存在复发性MN。对受者进行了检查，试图确定可能解释MN如此快速复发的体液免疫机制。
