Zhang Min, Xia Lixia, Peng Wenbei, Xie Guogang, Li Fei, Zhang Chao, Syeda Madiha Zahra, Hu Yue, Lan Fen, Yan Fugui, Jin Zhangchu, Du Xufei, Han Yinling, Lv Baihui, Wang Yuejue, Li Miao, Fei Xia, Zhao Yun, Chen Kaijun, Chen Yan, Li Wen, Chen Zhihua, Zhou Qiong, Zhang Min, Ying Songmin, Shen Huahao
Department of Respiratory and Critical Care Medicine, Key Laboratory of Respiratory Disease of Zhejiang Province, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, 310009, Zhejiang, China.
Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
NPJ Precis Oncol. 2024 Jun 29;8(1):138. doi: 10.1038/s41698-024-00608-8.
Malignant pleural effusion (MPE) is a common occurrence in advanced cancer and is often linked with a poor prognosis. Eosinophils were reported to involve in the development of MPE. However, the role of eosinophils in MPE remains unclear. To investigate this, we conducted studies using both human samples and mouse models. Increased eosinophil counts were observed in patients with MPE, indicating that the higher the number of eosinophils is, the lower the LENT score is. In our animal models, eosinophils were found to migrate to pleural cavity actively upon exposure to tumor cells. Intriguingly, we discovered that a deficiency in eosinophils exacerbated MPE, possibly due to their anti-tumor effects generated by modifying the microenvironment of MPE. Furthermore, our experiments explored the role of the C-C motif chemokine ligand 11 (CCL11) and its receptor C-C motif chemokine receptor 3 (CCR3) in MPE pathology. As a conclusion, our study underscores the protective potential of eosinophils against the development of MPE, and that an increase in eosinophils through adoptive transfer of eosinophils or increasing their numbers improved MPE.
恶性胸腔积液（MPE）在晚期癌症中很常见，且常与预后不良相关。据报道，嗜酸性粒细胞参与了MPE的发生发展。然而，嗜酸性粒细胞在MPE中的作用仍不清楚。为了研究这一问题，我们使用人类样本和小鼠模型进行了研究。在MPE患者中观察到嗜酸性粒细胞计数增加，这表明嗜酸性粒细胞数量越高，LENT评分越低。在我们的动物模型中，发现嗜酸性粒细胞在接触肿瘤细胞后会主动迁移到胸腔。有趣的是，我们发现嗜酸性粒细胞缺乏会加剧MPE，这可能是由于它们通过改变MPE的微环境产生了抗肿瘤作用。此外，我们的实验探讨了C-C基序趋化因子配体11（CCL11）及其受体C-C基序趋化因子受体3（CCR3）在MPE病理中的作用。总之，我们的研究强调了嗜酸性粒细胞对MPE发生发展的保护潜力，通过嗜酸性粒细胞的过继转移或增加其数量来增加嗜酸性粒细胞可改善MPE。
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