Hosseini Sayyid Ali
Mashhad University of Medical Sciences, Mashhad, Iran.
Nat Prod Res. 2025 Mar;39(6):1653-1657. doi: 10.1080/14786419.2024.2373955. Epub 2024 Jul 2.
Bladder cancer (BC) is one of the most common challenges endangering public health worldwide. Therefore, finding effective ways to prevent and treat this disease can significantly reduce the detrimental effects of BC. Baicalein is a compound derived from the root of Scutellaria baicalensis. This compound possesses anticancer potential because numerous studies have confirmed its effectiveness in improving breast, liver, colon, leukaemia, skin, and lung cancers. In this study, we focused on reviewing the latest research on the therapeutic effects of baicalein in treating BC. According to our findings in this review, baicalein, by affecting various signalling pathways such as AKT, MAPK, Survivin/CDC2, MMP, Bax/Bcl2, NF-kB, and Drp1, inducing cell death, and halting cellular growth in cancer cells, can be an appealing therapeutic approach in treating BC.
膀胱癌（BC）是全球范围内危害公众健康的最常见挑战之一。因此，找到预防和治疗这种疾病的有效方法可以显著降低膀胱癌的有害影响。黄芩素是一种从黄芩根部提取的化合物。这种化合物具有抗癌潜力，因为大量研究已证实其对乳腺癌、肝癌、结肠癌、白血病、皮肤癌和肺癌具有治疗效果。在本研究中，我们重点回顾了黄芩素治疗膀胱癌的最新研究。根据我们在本综述中的发现，黄芩素通过影响多种信号通路，如AKT、MAPK、Survivin/CDC2、MMP、Bax/Bcl2、NF-κB和Drp1，诱导细胞死亡，并阻止癌细胞的细胞生长，可能成为治疗膀胱癌的一种有吸引力的治疗方法。
