Adlercreutz H, Martin F, Järvenpää P, Fotsis T
Contraception. 1979 Sep;20(3):201-23. doi: 10.1016/0010-7824(79)90094-5.
A short review on steroid absorption and enterohepatic recycling in man with special emphasis on contraceptive and related steroids is presented. Some new experimental data on the intestinal metabolism of steroids is described and includes further observations on the effect of antimicrobial agents on steroid hormone metabolism. Evidence is presented that plasma levels of steroids may be influenced if the intestinal microflora is altered. Some formation of biologically active steroids, like estradiol, may occur in the intestinal tract and this may have both biological and pathological consequences and may be influenced by such factors as diet and sex. It is concluded that our knowledge of the intestinal and especially, the mucosal metabolism of steroids is scanty and further studies are needed to clarify the role of the intestine and enterohepatic circulation in determining the bioavailability of natural and synthetic steroids.
本文对人体中类固醇的吸收及肠肝循环进行了简短综述，特别强调了避孕药及相关类固醇。文中描述了一些关于类固醇肠道代谢的新实验数据，包括对抗菌剂对类固醇激素代谢影响的进一步观察。有证据表明，如果肠道微生物群发生改变，类固醇的血浆水平可能会受到影响。肠道中可能会形成一些具有生物活性的类固醇，如雌二醇，这可能会产生生物学和病理学后果，并且可能受到饮食和性别等因素的影响。结论是，我们对类固醇在肠道尤其是黏膜中的代谢了解甚少，需要进一步研究以阐明肠道和肠肝循环在决定天然和合成类固醇生物利用度方面的作用。
