Pham Nhi Thi Uyen, Nguyen Thuong Van, Nguyen Hao Trong
Ho Chi Minh City Hospital of Dermato-Venereology, Ho Chi Minh City.
Hanoi Medical University, Hanoi.
Dermatol Reports. 2023 Oct 16;16(2):9854. doi: 10.4081/dr.2023.9854. eCollection 2024 Jun 14.
Psoriasis is a chronic inflammatory skin disease that affects people all over the world. It is linked to the HLA-Cw6 allele, which is more common in Caucasians than in Asians and varies across ethnic groups. We investigated the association between the disease severity and the onset age of HLA-Cw6 prevalence in Vietnamese psoriasis patients. In 121 psoriasis patients and 30 healthy controls, we looked at the relationship between HLA-Cw6 and clinical features. We found that patients with psoriasis had significantly higher levels of HLA-Cw6 (64.5%) than controls (26.7%) (p=0.0001), with an odds ratio of 4.98 (2.04-12.15). Positive HLA-Cw6 patients had a significantly lower mean age of psoriasis onset than negative HLA-Cw6 patients. Patients with mild psoriasis (100%) were more likely to have the AA genotype, while patients with moderate to severe psoriasis (47.2% and 59.0%, respectively) and those with high PASI scores (55.1% and 54.1%, respectively) were more likely to have the TA genotype. Thus, HLA-Cw6 is a major genetic risk factor for psoriasis in Vietnamese patients, especially early-onset cases. Variations in HLA-Cw6 genotypes also affect disease severity.
银屑病是一种影响全球人群的慢性炎症性皮肤病。它与HLA - Cw6等位基因相关，该等位基因在白种人中比在亚洲人中更常见，且在不同种族群体中存在差异。我们调查了越南银屑病患者中疾病严重程度与HLA - Cw6患病率的发病年龄之间的关联。在121例银屑病患者和30例健康对照中，我们研究了HLA - Cw6与临床特征之间的关系。我们发现，银屑病患者的HLA - Cw6水平（64.5%）显著高于对照组（26.7%）（p = 0.0001），优势比为4.98（2.04 - 12.15）。HLA - Cw6阳性的患者银屑病发病的平均年龄显著低于HLA - Cw6阴性的患者。轻度银屑病患者（100%）更可能具有AA基因型，而中度至重度银屑病患者（分别为47.2%和59.0%）以及PASI评分高的患者（分别为55.1%和54.1%）更可能具有TA基因型。因此，HLA - Cw6是越南患者银屑病的主要遗传危险因素，尤其是早发型病例。HLA - Cw6基因型的变异也会影响疾病严重程度。
