National Cardiothoracic Centre, Korle Bu Teaching Hospital, Accra, Ghana.
Cardiothoracic Surgery Division, Surgery Department, Jos University Teaching Hospital, Jos, Nigeria.
Ghana Med J. 2023 Dec;57(4):262-269. doi: 10.4314/gmj.v57i4.2.
To determine the angiographic severity of coronary artery disease (CAD) and assess the influence of major cardiovascular risk factors (CVRF).
a cross-sectional, hospital-based study.
the catheterisation laboratory of the National Cardiothoracic Centre, Accra, Ghana.
for 12 months, consecutive patients admitted for coronary angiography were assessed for the presence of CVRFs. Those with significant CAD after angiography were recruited into the study.
The patient's angiograms were analysed, and the CAD severity was obtained using the SYNTAX scoring criteria.
The lesion overall severity (SYNTAX) score and the relationship with CVRFs present.
out of the 169 patients that had coronary angiography, 78 had significant CAD. The mean SYNTAX score was 20.18 (SD= 10.68), with a significantly higher value in dyslipidaemic patients (p < 0.001). Pearson's correlation between the score and BMI was weak (r= 0.256, p= 0.034). The occurrence of high SYNTAX score lesions in about 18% of the population was significantly associated with hypertension (OR= 1.304, 95% CI [1.13-1.50]; p= 0.017) dyslipidaemia (OR= 5.636, 95% CI [1.17-27.23]; p= 0.019), and obesity (OR= 3.960, 95% CI [1.18-13.34]; p= 0.021). However, after adjusting for confounding factors, only dyslipidaemia significantly influenced its occurrence (aOR= 5.256, 95% CI [1.03-26.96]; p= 0.047).
Even though the most severe form of CAD was found in about one-fifth of the study population, its occurrence was strongly influenced by the presence of dyslipidaemia.
None.
确定冠状动脉疾病（CAD）的血管造影严重程度，并评估主要心血管危险因素（CVRF）的影响。
横断面、基于医院的研究。
加纳阿克拉国家心胸中心的导管插入实验室。
在 12 个月的时间里，连续评估因冠状动脉造影入院的患者是否存在 CVRF。在血管造影后发现有明显 CAD 的患者被招募入组。
分析患者的血管造影，并使用 SYNTAX 评分标准获得 CAD 严重程度。
整体病变严重程度（SYNTAX）评分与存在的 CVRF 之间的关系。
在 169 例接受冠状动脉造影的患者中，78 例存在明显 CAD。平均 SYNTAX 评分为 20.18（标准差=10.68），血脂异常患者的评分明显更高（p<0.001）。评分与 BMI 之间的 Pearson 相关性较弱（r=0.256，p=0.034）。在人群中，约 18%发生高 SYNTAX 评分病变与高血压（OR=1.304，95%CI[1.13-1.50]；p=0.017）、血脂异常（OR=5.636，95%CI[1.17-27.23]；p=0.019）和肥胖（OR=3.960，95%CI[1.18-13.34]；p=0.021）显著相关。然而，在校正混杂因素后，只有血脂异常显著影响其发生（调整后的 OR=5.256，95%CI[1.03-26.96]；p=0.047）。
尽管在研究人群中约五分之一的人存在最严重的 CAD 形式，但它的发生受到血脂异常的强烈影响。
无。
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