Rhee J K, Baek B K, Ahn B Z
Am J Chin Med. 1985;13(1-4):119-25. doi: 10.1142/S0192415X85000162.
The effects of boiled water extracts of clonorchicidal raw drugs screened by the EPG counts in vivo on the structure of Clonorchis sinensis were investigated. The extracts of Cassia obutusifolia and Dictamnus dasycarpus did not seem to induce the morphological changes of the worms, and in those of Machilus thunbergii and Prunús mume, widening of bladder to lower level of seminal receptacle was visible without any other changes. Those of Inula helenium and Saussurea lappa, however, disclosed regressive and progressive changes as degeneration, atrophy, necrosis, dilatation, etc. of viscera of the worms. The recover rates of the worms from experimentally infected rabbits administered with the extracts of I. helenium and S. lappa for 30 days, beginning at the 3rd day of inoculation, were as low as 2% and 2.8%, respectively.
通过体内EPG计数筛选的杀华支睾吸虫生药的沸水提取物对中华支睾吸虫结构的影响进行了研究。决明子和白鲜皮的提取物似乎未引起虫体的形态变化，而在楠木和梅的提取物中，可见膀胱向受精囊较低水平增宽，无其他变化。然而，土木香和木香的提取物显示出虫体内脏的退行性和进行性变化，如变性、萎缩、坏死、扩张等。从接种后第3天开始，用土木香和木香提取物对实验感染兔给药30天，虫体的回收率分别低至2%和2.8%。
