Design, Synthesis, Nematicidal Evaluation, and Molecular Docking Study of Pyrano[3,2-]pyridones against .

Root-knot nematodes pose a serious threat to crops by affecting production and quality. Over a period of time, substantial work has been done toward the development of effective and environmentally benign nematicidal compounds. However, due to the inefficiencies of previously reported synthetics in achieving the target of safe, selective, and effective treatment, it is necessary to develop new efficacious and safer nematicidal agents considering human health and environment on top priority. This work aims to highlight the efficient and convenient l-proline catalyzed synthesis of pyrano[3,2-]pyridone and their use as potential nematicidal agents. results of larval mortality and egg hatching inhibition revealed maximum nematicidal activity against from compounds , , and with LC values of 28.8, 46.8, and 49.18 μg/mL at 48 h, respectively. Under similar conditions, pyrano[3,2-]pyridones derivatives (LC = 28.8 μg/mL) was found at par with LC (26.92 μg/mL) of commercial nematicide carbofuran. The results were further validated with studies with the most active compound nematicidal within the binding to the pocket of acetylcholine esterase (AChE). In docking, binding free energy values for compound were found to be -6.90 kcal/mol. Results indicated that pyrano[3,2-]pyridone derivatives have the potential to control .