• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Synthesis of Fully Substituted Pyrazoles with a Dicyanomethyl Group via DBU/Lewis Acid-Mediated Annulation of D-A Cyclopropanes with Arylhydrazines.

作者信息

Li Haiwen, Cheng Wenzhe, Lv Jiaman, Wang Cunde

机构信息

School of Chemistry and Chemical Engineering, Yangzhou University, 180 Siwangting Street, Yangzhou 225002, P. R. China.

出版信息

J Org Chem. 2024 Jul 19;89(14):10355-10362. doi: 10.1021/acs.joc.4c00919. Epub 2024 Jul 3.

DOI:10.1021/acs.joc.4c00919
PMID:38959522
Abstract

The efficient synthesis of fully substituted pyrazoles with a dicyanomethyl group was developed via an annulation reaction of 2-aroyl D-A cyclopropanes with arylhydrazines in the presence of DBU/AlCl reaction systems. This synthetic approach featured a wide range of readily available aroyl-substituted D-A cyclopropanes with diverse functional groups and a diversity of substituents on pyrazole products and had operationally simple and mild reaction conditions.

摘要

相似文献

1
Synthesis of Fully Substituted Pyrazoles with a Dicyanomethyl Group via DBU/Lewis Acid-Mediated Annulation of D-A Cyclopropanes with Arylhydrazines.
J Org Chem. 2024 Jul 19;89(14):10355-10362. doi: 10.1021/acs.joc.4c00919. Epub 2024 Jul 3.
2
Annulation of 2-Aroyl D-A Cyclopropanes via Selectively Ring-Opening Process with -Benzenediamines to Access Quinoxaline Derivatives.
J Org Chem. 2024 Jul 19;89(14):10333-10337. doi: 10.1021/acs.joc.4c00854. Epub 2024 Jul 2.
3
Acetic Acid-Catalyzed (3 + 2) Cyclization of 2-Aroyl-3-aryl-1,1-dicyanocyclopropanes with Arylhydrazines: To -4-Dicyanomethyl-1,3,5-triaryl-4,5-dihydropyrazoles.醋酸催化2-芳酰基-3-芳基-1,1-二氰基环丙烷与芳基肼的(3 + 2)环化反应：生成-4-二氰基甲基-1,3,5-三芳基-4,5-二氢吡唑。
J Org Chem. 2023 Nov 3;88(21):15478-15485. doi: 10.1021/acs.joc.3c01687. Epub 2023 Oct 12.
4
Tandem Dearomative/Rearomative (3 + 2) Annulation of Aroyl-Substituted Donor-Acceptor Cyclopropanes with Benzothiazoles.酰基取代的给体-受体环丙烷与苯并噻唑的串联去芳构化/再芳构化（3 + 2）环化反应。
J Org Chem. 2023 Mar 17;88(6):3903-3908. doi: 10.1021/acs.joc.2c02768. Epub 2023 Mar 6.
5
Direct synthesis of highly functionalized furans from donor-acceptor cyclopropanes via DBU-mediated ring expansion reactions.通过 DBU 介导的环扩张反应，从给体-受体环丙烷直接合成高官能化呋喃。
Org Biomol Chem. 2019 Aug 7;17(31):7342-7351. doi: 10.1039/c9ob01308c.
6
[3+3] Annulation of donor-acceptor cyclopropanes with mercaptoacetaldehyde: application to the synthesis of tetrasubstituted thiophenes.[3+3] 供体-受体环丙烷与巯基乙醛的环化反应：在合成四取代噻吩中的应用。
Chem Commun (Camb). 2014 Apr 21;50(31):4062-4. doi: 10.1039/c4cc00565a.
7
Divergent Reactivity of Thioalkynes in Lewis Acid Catalyzed Annulations with Donor-Acceptor Cyclopropanes.硫炔在路易斯酸催化下与给体-受体环丙烷进行环化反应时的不同反应活性。
Chemistry. 2016 Aug 16;22(34):11997-2001. doi: 10.1002/chem.201602755. Epub 2016 Jul 19.
8
Development of Synthetic Methodologies via Catalytic Enantioselective Synthesis of 3,3-Disubstituted Oxindoles.通过3,3-二取代氧化吲哚的催化对映选择性合成开发合成方法
Acc Chem Res. 2018 Jun 19;51(6):1443-1454. doi: 10.1021/acs.accounts.8b00097. Epub 2018 May 29.
9
Direct Construction of 1,4-Dihydropyridazines and Pyrazoles via Annulation of Alkyl 2-Aroyl-1-chlorocyclopropanecarboxylates.通过2-芳酰基-1-氯环丙烷羧酸烷基酯的环化反应直接构建1,4-二氢哒嗪和吡唑。
J Org Chem. 2024 Jul 19;89(14):9853-9860. doi: 10.1021/acs.joc.4c00520. Epub 2024 Jun 1.
10
Reactivity of Cross-Conjugated Enynones in Cyclocondensations with Hydrazines: Synthesis of Pyrazoles and Pyrazolines.交叉共轭烯炔酮与肼在环缩合反应中的反应活性：吡唑和吡唑啉的合成
J Org Chem. 2021 May 21;86(10):7229-7241. doi: 10.1021/acs.joc.1c00569. Epub 2021 May 6.