NTT Communication Science Laboratories, Atsugi, Kanagawa, Japan; Department of Informatics, Faculty of Information Science and Electrical Engineering, Kyushu University, Fukuoka, Japan.
NTT Communication Science Laboratories, Atsugi, Kanagawa, Japan.
Clin Neurophysiol. 2024 Sep;165:44-54. doi: 10.1016/j.clinph.2024.06.005. Epub 2024 Jun 15.
This study aimed to evaluate whether auditory brainstem response (ABR) using a paired-click stimulation paradigm could serve as a tool for detecting cochlear synaptopathy (CS).
The ABRs to single-clicks and paired-clicks with various inter-click intervals (ICIs) and scores for word intelligibility in degraded listening conditions were obtained from 57 adults with normal hearing. The wave I peak amplitude and root mean square values for the post-wave I response within a range delayed from the wave I peak (referred to as the RMS) were calculated for the single- and second-click responses.
The wave I peak amplitudes did not correlate with age except for the second-click responses at an ICI of 7 ms, and the word intelligibility scores. However, we found that the RMS values for the second-click responses significantly decreased with increasing age. Moreover, the RMS values for the second-click responses at an ICI of 5 ms correlated significantly with the scores for word intelligibility in degraded listening conditions.
The magnitude of the post-wave I response for the second-click response could serve as a tool for detecting CS in humans.
Our findings shed new light on the analytical methods of ABR for quantifying CS.
本研究旨在评估使用成对 click 刺激范式的听觉脑干反应 (ABR) 是否可作为检测耳蜗突触病 (CS) 的工具。
从 57 名听力正常的成年人中获得了单 click 和成对 click 的 ABR，刺激间隔时间（ICIs）各不相同，以及在听力下降条件下的单词可懂度评分。计算了单 click 和第二 click 反应的波 I 峰后响应的峰振幅和均方根值（RMS）。
除了 7 ms 的第二个 click 反应和单词可懂度评分与年龄无关外，波 I 峰振幅与年龄无相关性。然而，我们发现第二个 click 反应的 RMS 值随年龄的增加而显著降低。此外，5 ms 的第二个 click 反应的 RMS 值与听力下降条件下的单词可懂度评分显著相关。
第二个 click 反应的波 I 后响应幅度可作为检测人类 CS 的工具。
我们的发现为量化 CS 的 ABR 分析方法提供了新的思路。
