半球内背侧运动前区和初级运动皮层双部位经颅磁刺激连接性测量的重测信度

Test-retest reliability of intrahemispheric dorsal premotor and primary motor cortex dual-site TMS connectivity measures.

作者信息

Heemels Robin E, Ademi Sian, Hehl Melina

机构信息

Movement Control & Neuroplasticity Research Group, Department of Movement Sciences, Group Biomedical Sciences, KU Leuven, Heverlee, Belgium; KU Leuven, Leuven Brain Institute (LBI), Leuven, Belgium.

Movement Control & Neuroplasticity Research Group, Department of Movement Sciences, Group Biomedical Sciences, KU Leuven, Heverlee, Belgium; KU Leuven, Leuven Brain Institute (LBI), Leuven, Belgium; Neuroplasticity and Movement Control Research Group, Rehabilitation Research Institute (REVAL), Hasselt University, Diepenbeek, Belgium.

出版信息

Clin Neurophysiol. 2024 Sep;165:64-75. doi: 10.1016/j.clinph.2024.06.006. Epub 2024 Jun 19.

DOI:10.1016/j.clinph.2024.06.006

PMID:38959537

Abstract

OBJECTIVE

Investigating the optimal interstimulus interval (ISI) and the 24-hour test-retest reliability for intrahemispheric dorsal premotor cortex (PMd) - primary motor cortex (M1) connectivity using dual-site transcranial magnetic stimulation (dsTMS).

METHODS

In 21 right-handed adults, left intrahemispheric PMd-M1 connectivity has been investigated with a stacked-coil dsTMS setup (conditioning stimulus: 75% of resting motor threshold; test stimulus: eliciting MEPs of 1-1.5 mV) at ISIs of 3, 5-8, and 10 ms. Additionally, M1-M1 short-interval intracortical inhibition (SICI) and intracortical facilitation (ICF) were investigated to assess comparability to standard paired-pulse setups.

RESULTS

Conditioning PMd led to significant inhibition of M1 output at ISIs of 3 and 5 ms, whereas 10 ms resulted in facilitation (all, p < 0.001), with a fair test-retest reliability for 3 (ICC: 0.47) and 6 ms (ICC: 0.44) ISIs. Replication of SICI (p < 0.001) and ICF (p = 0.017) was successful, with excellent test-retest reliability for SICI (ICC: 0.81).

CONCLUSION

This dsTMS setup can probe the inhibitory and facilitatory PMd-M1 connections, as well as reliably replicate SICI and ICF paradigms.

SIGNIFICANCE

The stacked-coil dsTMS setup for investigating intrahemispheric PMd-M1 connectivity offers promising possibilities to better understand motor control.

摘要

目的

采用双部位经颅磁刺激（dsTMS）研究半球内背侧运动前区（PMd）-初级运动皮层（M1）连接的最佳刺激间隔（ISI）及24小时重测信度。

方法

对21名右利手成年人，使用叠层线圈dsTMS装置（条件刺激：静息运动阈值的75%；测试刺激：引出1-1.5 mV的运动诱发电位[MEP]），在3、5-8和10 ms的ISI下研究左侧半球内PMd-M1连接。此外，研究M1-M1短间隔皮质内抑制（SICI）和皮质内易化（ICF），以评估与标准配对脉冲装置的可比性。

结果

在3和5 ms的ISI下，刺激PMd导致M1输出显著抑制，而10 ms时则导致易化（均p<0.001），3 ms（组内相关系数[ICC]：0.47）和6 ms（ICC：0.44）ISI的重测信度尚可。SICI（p<0.001）和ICF（p = 0.017）的重复实验成功，SICI的重测信度极佳（ICC：0.81）。