Department of Nuclear Medicine, Cyclotron Research Center, Molecular Imaging and Therapeutic Medicine Research Center, Jeonbuk National University Medical School and Hospital, Jeonju, 54896, Republic of Korea.
Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, 54907, Republic of Korea.
Sci Rep. 2024 Jul 3;14(1):15264. doi: 10.1038/s41598-024-65256-1.
This study evaluated the use of F-18 fluorodeoxyglucose (FDG) PET/CT imaging to differentiate between scrub typhus and systemic lupus erythematosus (SLE) in patients presenting with lymphadenopathy. We carried out a retrospective analysis of 18 scrub typhus patients and seven SLE patients, using various imaging parameters, including lymph node size, spleen and liver lengths, the distance between the two farthest lesions (D), and assessments of glucose metabolism. On FDG PET images, we measured the maximum standardized uptake value (SUV) of the lymph nodes, spleen, and liver and the mean standardized uptake value (SUV) of the liver and spleen. The D values of scrub typhus patients were significantly longer than those of SLE patients, indicating that lymphadenopathy is more generalized in the patients with scrub typhus. The SUV values for the lymph node, spleen, and liver were also higher in patients with scrub typhus, while the SUV of the liver and spleen did not differ between the two groups. This study is the first to compare FDG PET/CT images between these two conditions, suggesting the potential of this imaging modality to provide critical diagnostic distinctions.
本研究评估了 F-18 氟代脱氧葡萄糖（FDG）PET/CT 成像在出现淋巴结病的患者中用于区分恙虫病和系统性红斑狼疮（SLE）的作用。我们对 18 例恙虫病患者和 7 例 SLE 患者进行了回顾性分析，使用了各种成像参数，包括淋巴结大小、脾脏和肝脏长度、最远病变之间的距离（D）以及葡萄糖代谢评估。在 FDG PET 图像上，我们测量了淋巴结、脾脏和肝脏的最大标准化摄取值（SUV）以及肝脏和脾脏的平均标准化摄取值（SUV）。恙虫病患者的 D 值明显长于 SLE 患者，表明恙虫病患者的淋巴结病更广泛。恙虫病患者的淋巴结、脾脏和肝脏的 SUV 值也更高，而两组之间的肝脏和脾脏 SUV 值没有差异。本研究首次比较了这两种情况的 FDG PET/CT 图像，表明这种成像方式有可能提供关键的诊断区别。
