Miyazaki M, Yamamoto M, Toda N
Arch Int Pharmacodyn Ther. 1985 Apr;274(2):210-22.
Angiotensin (ANG) II produced a slight, transient contraction followed by a moderate relaxation in dog renal artery strips precontracted with prostaglandin (PG) F2 alpha. Treatment with acetylsalicylic acid indomethacin, ibuprofen and sodium meclofenamate reduced the relaxant response to ANG II or reversed the relaxation to a contraction, but did not significantly alter the relaxant response to PGI2. The inhibitory potencies were in the order of meclofenamate greater than indomethacin greater than ibuprofen greater than acetylsalicylic acid. Sodium salicylate and gentisic acid, metabolites of acetylsalicylic acid, in concentrations up to 5 X 10(-4)M did not influence the ANG II-induced relaxation. Treatment with salicylate (5 X 10(-4)M) prevented the inhibitory effect of acetylsalicylic acid, indomethacin or meclofenamate, whereas combined treatment with salicylate and ibuprofen elicited an inhibition of ANG II-induced relaxations to a similar extent to that seen in preparations treated with ibuprofen alone. It appears that acetylsalicylic acid, indomethacin and meclofenamate share the same mechanism for inhibiting the cyclooxygenase activity, but the mechanism of inhibitory action of ibuprofen differs.
在预先用前列腺素（PG）F2α预收缩的犬肾动脉条中，血管紧张素（ANG）II产生轻微、短暂的收缩，随后是适度的舒张。用乙酰水杨酸、吲哚美辛、布洛芬和甲氯芬那酸钠处理可降低对ANG II的舒张反应或使舒张逆转至收缩，但对PGI2的舒张反应无显著影响。抑制效力顺序为甲氯芬那酸＞吲哚美辛＞布洛芬＞乙酰水杨酸。乙酰水杨酸的代谢产物水杨酸钠和龙胆酸，浓度高达5×10⁻⁴M时，不影响ANG II诱导的舒张。用5×10⁻⁴M水杨酸盐处理可防止乙酰水杨酸、吲哚美辛或甲氯芬那酸的抑制作用，而水杨酸盐和布洛芬联合处理对ANG II诱导的舒张的抑制程度与单独用布洛芬处理的制剂相似。似乎乙酰水杨酸、吲哚美辛和甲氯芬那酸在抑制环氧化酶活性方面具有相同的机制，但布洛芬的抑制作用机制不同。
