Kaplan B, Barnes L
Arch Otolaryngol. 1985 Aug;111(8):543-7. doi: 10.1001/archotol.1985.00800100091015.
A case of squamous cell carcinoma of the tongue arose in the plaque form of oral lichen planus. The literature on lichen planus is reviewed with emphasis on the issue of malignant transformation. Squamous carcinoma develops in 0.3% to 3% of patients with oral lichen planus (range, 0% to 10%). The average age of individuals with this complication is 50 to 55 years; 50% to 60% are men. Forty-four percent to 60% of patients have the erosive form of the disease, 28% to 34% plaque type, and 16% to 28% reticular. The mean interval from onset of the oral lesions to the development of cancer is nine to 12 years (range, three months to 40 years). Forty-six percent to 54% of the cancers occur on the buccal mucosa, 30% on the tongue, 16% on the lower lip, and 8% in miscellaneous sites. Twenty-four percent to 50% of the individuals also have cutaneous lichen planus.
一例舌鳞状细胞癌发生于口腔扁平苔藓的斑块型。本文回顾了有关扁平苔藓的文献，重点关注恶性转化问题。口腔扁平苔藓患者中0.3%至3%会发生鳞状细胞癌（范围为0%至10%）。出现这种并发症的个体平均年龄为50至55岁；50%至60%为男性。44%至60%的患者患有糜烂型疾病，28%至34%为斑块型，16%至28%为网状型。从口腔病变开始到癌症发生的平均间隔时间为9至12年（范围为3个月至40年）。46%至54%的癌症发生在颊黏膜，30%在舌部，16%在下唇，8%在其他部位。24%至50%的个体还患有皮肤扁平苔藓。
