Wu Haoxiang
Fudan University Shanghai Cancer Center, Shanghai, China.
Front Oncol. 2024 Jun 19;14:1409197. doi: 10.3389/fonc.2024.1409197. eCollection 2024.
Undifferentiated carcinoma with osteoclast-like giant cells of the pancreas (UCOGCP) is a rare pancreatic tumor that accounts for less than 1% of all pancreatic malignancies. The characteristic pathological manifestation of UCOGCP is the presence of osteoclast-like giant cells (OGCs) distributed among pleomorphic undifferentiated tumor cells. UCOGCP can occur either alone or in association with other types of pancreatic tumors. At present, there is no unified consensus or guideline for the diagnosis and treatment of UCOGCP, and most of the literature are individual case reports. With the accumulation in the number of clinical cases and the development of precision medicine technology, the understanding of UCOGCP is also deepening. Researchers have begun to recognize that UCOGCP is a pancreatic tumor with distinctive clinical and molecular characteristics. In this review, we focus on the latest research status and future exploration directions in the diagnosis, treatment, and prognosis of UCOGCP.
胰腺破骨细胞样巨细胞未分化癌（UCOGCP）是一种罕见的胰腺肿瘤，占所有胰腺恶性肿瘤的比例不到1%。UCOGCP的特征性病理表现是破骨细胞样巨细胞（OGCs）分布于多形性未分化肿瘤细胞之间。UCOGCP可单独发生，也可与其他类型的胰腺肿瘤相关。目前，对于UCOGCP的诊断和治疗尚无统一的共识或指南，大多数文献为个案报道。随着临床病例数量的积累和精准医学技术的发展，对UCOGCP的认识也在不断加深。研究人员已开始认识到UCOGCP是一种具有独特临床和分子特征的胰腺肿瘤。在本综述中，我们重点关注UCOGCP在诊断、治疗和预后方面的最新研究现状及未来探索方向。
