Department of Pathology, 3rd Faculty of Medicine, Charles University, University Hospital Kralovske Vinohrady, 100 34 Prague, Czech Republic.
Central Laboratories, University Hospital Kralovske Vinohrady, 100 34 Prague, Czech Republic.
Int J Mol Sci. 2024 Mar 14;25(6):3285. doi: 10.3390/ijms25063285.
Undifferentiated carcinoma with osteoclast-like giant cells (UCOGC) of the pancreas is a rare malignancy regarded as a subvariant of pancreatic ductal carcinoma (PDAC) characterized by variable prognosis. UCOGC shows a strikingly similar spectrum of oncogenic DNA mutations to PDAC. In the current work, we analyzed the landscape of somatic mutations in a set of 13 UCOGC cases via next-generation sequencing (NGS). We detected a spectrum of pathogenic or likely pathogenic mutations similar to those observed in PDAC following previously published results (10 , 9 , 4 , and 1 , , , , , , , , and ). Our results support the theory that UCOGC is a variant of PDAC, despite its unique morphology; however, a UCOGC-specific genomic signature as well as predictive markers remain mainly unknown. Programmed death ligand 1 (PD-L1) status remains an important predictive marker based on previous studies.
胰腺的未分化癌伴破骨样巨细胞（UCOGC）是一种罕见的恶性肿瘤，被认为是胰腺导管腺癌（PDAC）的一个亚型，其预后存在差异。UCOGC 表现出与 PDAC 非常相似的致癌 DNA 突变谱。在目前的工作中，我们通过下一代测序（NGS）分析了一组 13 例 UCOGC 病例的体细胞突变图谱。我们检测到了一系列与之前发表的结果类似的致病性或可能致病性突变（10 、9 、4 、和 1 、 、 、 、 、 、 、 、 、 、 ）。我们的结果支持 UCOGC 是 PDAC 的一种变体的理论，尽管其形态独特；然而，UCOGC 特有的基因组特征和预测标志物仍然主要未知。根据之前的研究，程序性死亡配体 1（PD-L1）状态仍然是一个重要的预测标志物。
