Kilworth L, Crane D, Masters C
Biochem Int. 1985 Apr;10(4):539-47.
The effects of insulin on the balance of lipid metabolism have been investigated by measuring the relative in vivo incorporation of 3H- and 14C-labelled glycerol into the major tissues and lipid classes of diabetic mice over a three day period. Several significant alterations in the relative uptake of label were caused by the insulin treatment. Generally, there were indications of decreased synthesis and degradation of lipids in most tissues, but with an increased synthesis of hepatic triacylglycerol being a notable exception to these trends. These data indicate that insulin treatment produces widespread changes in the relative emphasis of lipid metabolism, and allow a detailed description of these responses in relation to the individual tissues and lipid classes of the living animal. The implications of these metabolic changes have been discussed in relation to hormonal effects, and tissue specific and whole body aspects of the regulation of lipid metabolism.
通过在三天时间内测量3H和14C标记的甘油在糖尿病小鼠主要组织和脂质类别中的相对体内掺入量，研究了胰岛素对脂质代谢平衡的影响。胰岛素治疗引起了标记物相对摄取的若干显著变化。一般来说，大多数组织中脂质的合成和降解有减少的迹象，但肝脏三酰甘油合成增加是这些趋势的一个显著例外。这些数据表明，胰岛素治疗会使脂质代谢的相对重点发生广泛变化，并能详细描述这些反应与活体动物个体组织和脂质类别的关系。已结合激素效应以及脂质代谢调节的组织特异性和全身方面讨论了这些代谢变化的意义。
