维生素D状态与甲状腺癌之间的关联：一项荟萃分析。
Association between vitamin D status and thyroid cancer: a meta-analysis.
作者信息
Hu Yue, Xue Chongxiang, Ren Shumeng, Dong Lishuo, Gao Jiaqi, Li Xiuyang
机构信息
Institute of Metabolic Diseases, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Qi-Huang Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.
出版信息
Front Nutr. 2024 Jun 18;11:1423305. doi: 10.3389/fnut.2024.1423305. eCollection 2024.
BACKGROUND
Cumulative evidence has suggested that vitamin D deficiency is related with an increased susceptibility to various types of cancers. However, the association between vitamin D and thyroid cancer (TC) has remained to be unknown. Thus, there has been an urgent need for a meta-analysis to summarize existing evidence on vitamin D levels and the risk of TC.
OBJECTIVE
This meta-analysis aimed to figure out the association between vitamin D level and the risk of TC.
METHODS
A systematic search was performed for eligible articles on the association between vitamin D and TC based on PubMed, Embase, Web of Science, Cochrane, and ClinicalTrials.gov. Outcomes were the vitamin D level of cases with TC and the incidence of vitamin D deficiency in cases with TC comparing with the controls. The effect measures included standardized mean difference (SMD), ratio of means (RoM), and odds ratio (OR). A dose-response meta-analysis was performed to assess the correlation between vitamin D level and the risk of TC. Subgroup analyses and meta-regressions were conducted to explore the source of heterogeneity. And publication bias was evaluated through Begg's and Egger's tests.
RESULTS
Results of the meta-analysis revealed lower levels of vitamin D in TC cases comparing with those in control [SMD = -0.25, 95% CI: (-0.38, -0.12); RoM = 0.87, 95% CI: (0.81, 0.94)] and the levels of 1,25 (OH)D in cases with TC were also lower than controls [SMD = -0.49, 95% CI: (-0.80, -0.19); RoM = 0.90, 95% CI: (0.85, 0.96)]. And vitamin D deficiency was associated with the increased risk of TC [OR = 1.49, 95% CI: (1.23, 1.80)]. Additionally, results from the dose-response meta-analysis showed that there is a 6% increase in the risk of TC for each 10 ng/ml decrease in 25 (OH)D levels [OR = 0.94; 95% CI: (0.89, 0.99)].
CONCLUSIONS
Individuals with TC had lower levels of vitamin D compared to controls, and vitamin D deficiency was correlated with an increase risk of TC.
SYSTEMATIC REVIEW REGISTRATION
https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=504417, identifier: CRD42024504417.
背景
越来越多的证据表明，维生素D缺乏与多种癌症易感性增加有关。然而，维生素D与甲状腺癌（TC）之间的关联尚不清楚。因此，迫切需要进行一项荟萃分析，以总结关于维生素D水平与TC风险的现有证据。
目的
本荟萃分析旨在明确维生素D水平与TC风险之间的关联。
方法
基于PubMed、Embase、Web of Science、Cochrane和ClinicalTrials.gov对关于维生素D与TC关联的合格文章进行系统检索。结果指标为TC患者的维生素D水平以及TC患者与对照组相比维生素D缺乏的发生率。效应量包括标准化均数差（SMD）、均数比（RoM）和比值比（OR）。进行剂量反应荟萃分析以评估维生素D水平与TC风险之间的相关性。进行亚组分析和荟萃回归以探索异质性来源。并通过Begg检验和Egger检验评估发表偏倚。
结果
荟萃分析结果显示，TC患者的维生素D水平低于对照组[SMD = -0.25，95%CI：（-0.38，-0.12）；RoM = 0.87，95%CI：（0.81，0.94）]，TC患者的1,25（OH）D水平也低于对照组[SMD = -0.49，95%CI：（-0.80，-0.19）；RoM = 0.90，95%CI：（0.85，0.96）]。维生素D缺乏与TC风险增加相关[OR = 1.49，95%CI：（1.23，1.80）]。此外，剂量反应荟萃分析结果显示，25（OH）D水平每降低10 ng/ml，TC风险增加6%[OR = 0.94；95%CI：（0.89，0.99）]。
结论
与对照组相比，TC患者的维生素D水平较低，维生素D缺乏与TC风险增加相关。
系统评价注册
https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=504417，标识符：CRD42024504417。
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