Institute of Biomedical Research, Yunnan University, Kunming, China.
Southwest United Graduate School, Kunming, China.
Bioessays. 2024 Sep;46(9):e2400091. doi: 10.1002/bies.202400091. Epub 2024 Jul 4.
The cGAS-STING signaling pathway plays a pivotal role in sensing cytosolic DNA and initiating innate immune responses against various threats, with disruptions in this pathway being associated with numerous immune-related disorders. Therefore, precise regulation of the cGAS-STING signaling is crucial to ensure appropriate immune responses. Recent research, including ours, underscores the importance of protein condensation in driving the activation and maintenance of innate immune signaling within the cGAS-STING pathway. Consequently, targeting condensation processes in this pathway presents a promising approach for modulating the cGAS-STING signaling and potentially managing associated disorders. In this review, we provide an overview of recent studies elucidating the role and regulatory mechanism of protein condensation in the cGAS-STING signaling pathway while emphasizing its pathological implications. Additionally, we explore the potential of understanding and manipulating condensation dynamics to develop novel strategies for mitigating cGAS-STING-related disorders in the future.
cGAS-STING 信号通路在检测细胞溶质 DNA 和启动针对各种威胁的固有免疫反应方面发挥着关键作用，该通路的中断与许多免疫相关疾病有关。因此，精确调节 cGAS-STING 信号对于确保适当的免疫反应至关重要。最近的研究，包括我们的研究，强调了蛋白质凝聚在驱动 cGAS-STING 途径中的固有免疫信号的激活和维持中的重要性。因此，靶向该途径中的凝聚过程是调节 cGAS-STING 信号并可能管理相关疾病的有前途的方法。在这篇综述中，我们概述了最近的研究，阐明了蛋白质凝聚在 cGAS-STING 信号通路中的作用和调节机制，同时强调了其病理意义。此外，我们探讨了理解和操纵凝聚动力学的潜力，以制定未来减轻与 cGAS-STING 相关疾病的新策略。
