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Binding of the antitumor drug cis-diamminedichloroplatinum(II) (cisplatin) to DNA.

作者信息

Pinto A L, Lippard S J

出版信息

Biochim Biophys Acta. 1985;780(3):167-80. doi: 10.1016/0304-419x(85)90001-0.

DOI:10.1016/0304-419x(85)90001-0
PMID:3896310
Abstract
摘要

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An in vitro characterization of interstrand cross-links in DNA exposed to the antitumor drug cis-dichlorodiammineplatinum(II).
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cis-Diamminedichloroplatinum(II) selectively cross-links high mobility group proteins 1 and 2 to DNA in micrococcal nuclease accessible regions of chromatin.顺二氯二氨合铂（II）在染色质的微球菌核酸酶可及区域将高迁移率族蛋白1和2选择性地交联到DNA上。
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Mode of DNA binding of cis-platinum(II) antitumor drugs: a base sequence-dependent mechanism is proposed.
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Proc Natl Acad Sci U S A. 1982 Jun;79(11):3489-92. doi: 10.1073/pnas.79.11.3489.

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