Department of Neurology, Washington University in St. Louis, St. Louis, MO, USA.
Mallinckrodt Institute of Radiology, Washington University in St. Louis, St. Louis, MO, USA.
Ann Neurol. 2024 Sep;96(3):453-459. doi: 10.1002/ana.27027. Epub 2024 Jul 4.
The life expectancy of people with multiple sclerosis (MS) has increased, yet we have noted that development of a typical Alzheimer disease dementia syndrome is uncommon. We hypothesized that Alzheimer disease pathology is uncommon in MS patients. In 100 MS patients, the rate of amyloid-β plasma biomarker positivity was approximately half the rate in 300 non-MS controls matched on age, sex, apolipoprotein E proteotype, and cognitive status. Interestingly, most MS patients who did have amyloid-β pathology had features atypical for MS at diagnosis. These results support that MS is associated with reduced Alzheimer disease risk, and suggest new avenues of research. ANN NEUROL 2024;96:453-459.
多发性硬化症(MS)患者的预期寿命有所增加,但我们注意到,典型的阿尔茨海默病痴呆综合征并不常见。我们假设阿尔茨海默病病理学在 MS 患者中并不常见。在 100 名 MS 患者中,淀粉样蛋白-β 血浆生物标志物阳性率约为 300 名非 MS 对照者的一半,这些对照者在年龄、性别、载脂蛋白 E 表型和认知状态方面相匹配。有趣的是,大多数患有淀粉样蛋白-β 病理学的 MS 患者在诊断时具有非典型的 MS 特征。这些结果支持 MS 与降低阿尔茨海默病风险有关,并为新的研究途径提供了依据。神经病学年鉴 2024;96:453-459.