Bishop M C, Ansell I D, Taylor M C, Thomas A L
Br J Urol. 1985 Aug;57(4):453-7. doi: 10.1111/j.1464-410x.1985.tb06309.x.
Serial transrectal needle biopsies were taken from 146 patients (657 specimens) with advanced prostatic cancer (T3/T4, M1/MO) admitted to a trial of two forms of oestrogen therapy. Histological grading by Gleason and Mostofi techniques on the initial biopsy showed no correlation either with extent of disease or its eventual outcome on treatment. Change in grade was dissociated from the response of bone metastases to hormone treatment and did not appear to influence survival. However, the prognosis of 16 patients showing clearance of tumour from their serial biopsies was generally good.
对146例（657份标本）晚期前列腺癌（T3/T4，M1/M0）患者进行了系列经直肠针吸活检，这些患者参加了两种雌激素治疗形式的试验。初次活检时采用Gleason和Mostofi技术进行的组织学分级与疾病范围或其最终治疗结果均无相关性。分级变化与骨转移对激素治疗的反应无关，似乎也不影响生存率。然而，16例系列活检显示肿瘤清除的患者预后总体良好。
