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少突胶质细胞前体细胞:新生儿脑缺氧后髓鞘修复的无名英雄。

Pericytes: Unsung heroes in myelin repair after neonatal brain hypoxia.

机构信息

University of Coimbra, Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), 3000-548 Coimbra, Portugal; University of Coimbra, Institute for Nuclear Sciences Applied to Health (ICNAS), 3000-548 Coimbra, Portugal; University of Coimbra, Institute of Physiology, 3000-548 Coimbra, Portugal.

Center for Developmental Biology and Regenerative Medicine, Seattle Children's Research Institute, Seattle, WA, USA, 98101; Department of Pediatrics, University of Washington, Seattle, WA 98195 USA; Department of Bioengineering, University of Washington, Seattle, WA 98195, USA.

出版信息

Neuron. 2024 Jul 3;112(13):2081-2083. doi: 10.1016/j.neuron.2024.05.030.

Abstract

Preterm infants can face lasting neurodevelopmental challenges due to hypoxia-induced injury of the cerebral white matter. In this issue of Neuron, Ren et al. identify microvascular pericytes as unexpected targets for growth hormone signaling, which enhances angiogenesis and remyelination after hypoxic injury in the developing mouse brain.

摘要

早产儿由于缺氧引起的大脑白质损伤可能面临持久的神经发育挑战。在本期《神经元》杂志中,Ren 等人发现微血管周细胞是生长激素信号的意外靶点,它可以增强发育中老鼠大脑缺氧损伤后的血管生成和髓鞘再生。

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