Graduate Program in Public Health, Federal University of Rio Grande do Norte, Natal, Brazil.
Graduate Program in Rehabilitation Science, Federal University of Rio Grande do Norte, Natal, Brazil.
Eur Addict Res. 2024;30(4):197-206. doi: 10.1159/000535720. Epub 2024 Jul 4.
Craving is a multifactorial behavior caused by central circuit imbalance. The proposed treatments involve exercise and reduced food intake. However, the treatments frequently fail. This study aimed to investigate the effect of 10 consecutive sessions of anodal transcranial direct current stimulation over the right dorsolateral prefrontal cortex on food craving and eating consumption of women affected by overweight and obesity.
A randomized double-blind controlled trial with 50 volunteers was divided into two groups (active-tDCS: n = 25 and sham-tDCS: n = 25). There were a total of 10 consecutive tDCS sessions (2 mA, for 20 min) with an F4 anodal-F3 cathodal montage. We evaluated the effects on eating behavior (food craving, uncontrolled eating, emotional eating, and cognitive restriction), food consumption (calories and macronutrients), and anthropometric and body composition variables (weight, body mass index, waist circumference, and body fat percentage).
There were no statistically significant results between groups at the baseline regarding sociodemographic and clinical characteristics. Also, there was no significant interaction between time versus group for any of the variables studied. Treatment with tDCS was well tolerated and there were no serious adverse effects.
In women affected by overweight and obesity with food cravings, 10 sessions of F4 (anodal) and F3 (cathodal) tDCS did not produce changes in eating behavior, food consumption, and anthropometric and body composition.
craving 是一种由中枢电路失衡引起的多因素行为。现有的治疗方法包括运动和减少食物摄入。然而，这些治疗方法常常失败。本研究旨在探讨连续 10 次右背外侧前额叶皮层阳极经颅直流电刺激对超重和肥胖女性 craving 和进食量的影响。
一项随机双盲对照试验，共有 50 名志愿者被分为两组（真刺激组：n = 25；假刺激组：n = 25）。共有 10 次连续的 tDCS 治疗（2 mA，20 分钟），采用 F4 阳极-F3 阴极的刺激模式。我们评估了治疗对进食行为（craving、失控进食、情绪进食和认知限制）、食物摄入（卡路里和宏量营养素）以及人体测量和身体成分变量（体重、体重指数、腰围和体脂百分比）的影响。
在基线时，两组的社会人口统计学和临床特征没有统计学差异。此外，在研究的任何变量中，时间与组之间均无显著交互作用。tDCS 治疗耐受良好，无严重不良事件。
在有 craving 的超重和肥胖女性中，连续 10 次 F4（阳极）和 F3（阴极）tDCS 治疗并未改变进食行为、食物摄入以及人体测量和身体成分。
