• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Perifused monolayer cultures of rat hepatocytes as an improved in vitro system for studies on ureogenesis.

作者信息

Gebhardt R, Mecke D

出版信息

Exp Cell Res. 1979 Dec;124(2):349-59. doi: 10.1016/0014-4827(79)90210-6.

DOI:10.1016/0014-4827(79)90210-6
PMID:389647
Abstract
摘要

相似文献

1
Perifused monolayer cultures of rat hepatocytes as an improved in vitro system for studies on ureogenesis.大鼠肝细胞的灌流单层培养作为一种用于尿素生成研究的改进体外系统。
Exp Cell Res. 1979 Dec;124(2):349-59. doi: 10.1016/0014-4827(79)90210-6.
2
Permissive effect of dexamethasone on glucagon induction of urea-cycle enzymes in perifused primary monolayer cultures of rat hepatocytes.地塞米松对原代大鼠肝细胞单层灌流培养中胰高血糖素诱导尿素循环酶的允许作用。
Eur J Biochem. 1979 Jun;97(1):29-35. doi: 10.1111/j.1432-1033.1979.tb13082.x.
3
Metabolic and enzymatic characteristics of adult rat liver parenchymal cells in non-proliferating primary monolayer cultures.非增殖性原代单层培养成年大鼠肝脏实质细胞的代谢和酶学特性
Exp Cell Res. 1978 Mar 15;112(2):431-41. doi: 10.1016/0014-4827(78)90225-2.
4
Arginase release by primary hepatocytes and liver slices results in rapid conversion of arginine to urea in cell culture media.原代肝细胞和肝切片释放的精氨酸酶会导致细胞培养基中的精氨酸迅速转化为尿素。
Toxicol In Vitro. 2008 Jun;22(4):1094-8. doi: 10.1016/j.tiv.2008.01.016. Epub 2008 Feb 8.
5
Effects of triglyceride accumulation on induction of urea synthesis by glucagon and dexamethasone in monolayer cultures of bovine hepatocytes.甘油三酯积累对胰高血糖素和地塞米松诱导牛肝细胞单层培养物中尿素合成的影响。
J Anim Sci. 2000 Jun;78(6):1659-66. doi: 10.2527/2000.7861659x.
6
Effects of phorbol esters on alpha 1-adrenergic-mediated and glucagon-mediated actions in isolated rat hepatocytes.佛波酯对离体大鼠肝细胞中α1-肾上腺素能介导及胰高血糖素介导作用的影响。
Biochem J. 1985 May 15;228(1):277-80. doi: 10.1042/bj2280277.
7
Oxygen tension does not affect urea synthesis in perifused rat hepatocytes.氧张力不影响灌流大鼠肝细胞中的尿素合成。
Eur J Biochem. 1991 Jan 30;195(2):455-7. doi: 10.1111/j.1432-1033.1991.tb15725.x.
8
A high density culture of hepatocytes using a reticulated polyvinyl formol resin.使用网状聚乙烯醇缩甲醛树脂进行肝细胞的高密度培养。
ASAIO Trans. 1990 Jul-Sep;36(3):M727-9.
9
[Study of ureogenesis in liver cirrhosis by determination of ornithine carbamoyl- transferase and arginase activity in hepatic biopsy specimens].
Pathol Biol (Paris). 1973 Sep;21(7):717-23.
10
The hormonal stimulation of ureogenesis in isolated hepatocytes through increases in mitochondrial ATP production.通过增加线粒体ATP生成对分离的肝细胞中尿素生成的激素刺激。
Arch Biochem Biophys. 1980 Apr 15;201(1):44-55. doi: 10.1016/0003-9861(80)90485-3.

引用本文的文献

1
Three-dimensional (3D) liver cell models - a tool for bridging the gap between animal studies and clinical trials when screening liver accumulation and toxicity of nanobiomaterials.三维（3D）肝细胞模型——在筛选纳米生物材料的肝脏蓄积和毒性的临床试验中，连接动物研究和临床试验的桥梁的工具。
Drug Deliv Transl Res. 2022 Sep;12(9):2048-2074. doi: 10.1007/s13346-022-01147-0. Epub 2022 May 4.
2
Primary Hepatocytes Cultured on a Fiber-Embedded PDMS Chip to Study Drug Metabolism.培养在纤维嵌入聚二甲基硅氧烷芯片上的原代肝细胞用于研究药物代谢。
Polymers (Basel). 2017 Jun 10;9(6):215. doi: 10.3390/polym9060215.
3
Advancements in in vitro hepatic models: application for drug screening and therapeutics.
体外肝脏模型的进展：在药物筛选和治疗中的应用
Hepatol Int. 2014 Jan;8(1):23-38. doi: 10.1007/s12072-013-9490-8. Epub 2013 Dec 5.
4
Microengineered cell and tissue systems for drug screening and toxicology applications: Evolution of liver technologies.用于药物筛选和毒理学应用的微工程细胞和组织系统：肝脏技术的发展
Technology (Singap World Sci). 2015 Mar;3(1):1-26. doi: 10.1142/S2339547815300012.
5
Multi-cellular 3D human primary liver cell culture elevates metabolic activity under fluidic flow.多细胞3D人原代肝细胞培养在流体流动下提高代谢活性。
Lab Chip. 2015 May 21;15(10):2269-77. doi: 10.1039/c5lc00237k.
6
Bioreactor technologies to support liver function in vitro.支持体外肝功能的生物反应器技术。
Adv Drug Deliv Rev. 2014 Apr;69-70:132-57. doi: 10.1016/j.addr.2014.02.011. Epub 2014 Mar 5.
7
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.近年来，利用原代肝细胞、替代的肝细胞来源和非实质细胞的 2D 和 3D 体外系统在研究肝毒性、细胞信号转导和 ADME 的机制方面取得了进展。
Arch Toxicol. 2013 Aug;87(8):1315-530. doi: 10.1007/s00204-013-1078-5. Epub 2013 Aug 23.
8
Organotypic liver culture models: meeting current challenges in toxicity testing.器官型肝培养模型：应对当前毒性测试的挑战。
Crit Rev Toxicol. 2012 Jul;42(6):501-48. doi: 10.3109/10408444.2012.682115. Epub 2012 May 15.
9
Perifusion of co-cultured hepatocytes: optimization of studies on drug metabolism and cytotoxicity in vitro.共培养肝细胞的灌流：体外药物代谢和细胞毒性研究的优化
Cell Biol Toxicol. 1996 Apr;12(2):57-68. doi: 10.1007/BF00143356.
10
The Chamber/Dish: an improved vessel for cell and explant culture.培养室/培养皿：一种用于细胞和外植体培养的改良容器。
In Vitro. 1981 Feb;17(2):91-7. doi: 10.1007/BF02618064.