Hamlet S M, Tunny T J, Woodland E, Gordon R D
Clin Exp Pharmacol Physiol. 1985 May-Jun;12(3):249-52. doi: 10.1111/j.1440-1681.1985.tb02641.x.
The ratio of aldosterone to renin in plasma was measured in samples collected from 79 hypertensive patients. Eighteen patients with primary aldosteronism had ratios ranging from 25 to 677 (mean 183) when measured on 34 occasions, while 16 normal subjects had ratios of 3.3-21 (mean 11.3). Of the remaining 61 patients with ratios ranging from 1.8 to 184, 15 patients have ratios greater than 25 and are under investigation for primary aldosteronism, which appears highly likely in five and has been excluded in two. The aldosterone/renin ratio appears promising as a screening test for primary aldosteronism. Consistency and the effects of sodium and potassium balance and of antihypertensive medications require further study.
对79名高血压患者采集的样本测定了血浆中醛固酮与肾素的比率。18例原发性醛固酮增多症患者在34次检测中该比率范围为25至677（平均183），而16名正常受试者的比率为3.3至21（平均11.3）。其余61例患者的比率范围为1.8至184，其中15例患者的比率大于25，正在接受原发性醛固酮增多症的调查，其中5例似乎很可能患有该病，2例已被排除。醛固酮/肾素比率作为原发性醛固酮增多症的筛查试验似乎很有前景。钠钾平衡和抗高血压药物的一致性及影响需要进一步研究。
