Clin Lab. 2024 Jul 1;70(7). doi: 10.7754/Clin.Lab.2024.240212.
Mean corpuscular hemoglobin concentration (MCHC) is one of the parameters detected by blood cell analyzers, often used together with mean corpuscular volume (MCV) and mean corpuscular hemoglobin content (MCH) as diagnostic indicators for anemia classification. It has important clinical value in early detection of the cause of anemia and the underlying etiology of anemia. Therefore, the accuracy of MCHC results is of great significance for the diagnosis and treatment of diseases.
We reported two cases of false elevation of MCHC. Considering the possibility of cold agglutination and lipid blood interference detection, we used 37℃ water bath and plasma exchange to correct for interference on the sample.
After correcting the interference, MCHC returned to normal, consistent with the patient's disease status. Therefore, the two cases of abnormal elevation of MCHC are considered to be pseudo elevation caused by interference.
For specimens with abnormally elevated MCHC levels, experimenters should first analyze possible interfering factors and choose effective methods to correct different interferences, providing accurate testing reports for doctors and patients.
平均红细胞血红蛋白浓度（MCHC）是血细胞分析仪检测的参数之一，常与平均红细胞体积（MCV）和平均红细胞血红蛋白含量（MCH）一起作为贫血分类的诊断指标。它在早期发现贫血的原因和贫血的潜在病因方面具有重要的临床价值。因此，MCHC 结果的准确性对疾病的诊断和治疗具有重要意义。
我们报告了两例 MCHC 假性升高的病例。考虑到冷自身免疫性溶血性贫血和脂血干扰检测的可能性，我们使用 37℃水浴和血浆置换来纠正样本干扰。
干扰纠正后，MCHC 恢复正常，与患者的病情相符。因此，这两例 MCHC 异常升高被认为是干扰引起的假性升高。
对于 MCHC 水平异常升高的标本，实验人员应首先分析可能的干扰因素，并选择有效的方法纠正不同的干扰，为医生和患者提供准确的检测报告。
