Institute of Mental Health, Tianjin Anding Hospital, Mental Health Center of Tianjin Medical University, Tianjin, 300222, China.
Brain Assessment & Intervention Laboratory, Tianjin Anding Hospital, Mental Health Center of Tianjin Medical University, Tianjin, 300222, China.
J Neural Transm (Vienna). 2024 Sep;131(9):1047-1057. doi: 10.1007/s00702-024-02802-1. Epub 2024 Jul 5.
Brain-derived neurotrophic factor (BDNF) and glycolipid metabolism have been implicated in cognitive impairments and depression among Parkinson's disease (PD). However, the role of sex differences in this relationship remains elusive. This study aimed to investigate the potential sex differences in the link between serum BDNF levels, glycolipid metabolism and cognitive performance among depressive PD patients. PD patients comprising 108 individuals with depression and 108 without depression were recruited for this study. Cognitive function was assessed using the Montreal Cognitive Assessment Beijing version (MOCA-BJ). The severity of depressive symptoms was assessed using the Hamilton Depression Rating Scale (HAMD-17), while motor symptoms were evaluated using the Revised Hoehn and Yahr rating scale (H-Y) and the Unified Parkinson's Disease Rating Scale Part III (UPDRS-III). Laboratory testing and enzyme-linked immunosorbent assay (ELISA) are used to measure serum levels of glycolipid metabolism and BDNF. Females showed superior performance in delayed recall (all p < 0.05), male PD patients exhibited higher scores in naming tasks compared to females in non-depression group. There was no sex differences in serum BDNF levels between depression and non-depression groups. Liner regression analysis indicated BDNF as an independent risk factor for language deficits in male PD patients with depression (p < 0.05), while cholesterol (CHOL) emerged as a cognitive influencing factor, particularly in delayed recall among male PD patients with depression (p < 0.05). Our study reveals extensive cognitive impairments in PD patients with depression. Moreover, BDNF and CHOL may contribute to the pathological mechanisms underlying cognitive deficits, particularly in male patients with depression.
脑源性神经营养因子 (BDNF) 和糖脂代谢与帕金森病 (PD) 患者的认知障碍和抑郁有关。然而，这种关系中性别差异的作用仍不清楚。本研究旨在探讨抑郁性 PD 患者血清 BDNF 水平、糖脂代谢与认知功能之间潜在的性别差异。本研究招募了 108 例抑郁和 108 例无抑郁的 PD 患者。使用蒙特利尔认知评估北京版 (MOCA-BJ) 评估认知功能。使用汉密尔顿抑郁评定量表 (HAMD-17) 评估抑郁症状严重程度，使用修订的 Hoehn 和 Yahr 评分量表 (H-Y) 和统一帕金森病评定量表第三部分 (UPDRS-III) 评估运动症状。实验室检测和酶联免疫吸附试验 (ELISA) 用于测量血清糖脂代谢和 BDNF 水平。女性在延迟回忆方面表现出更好的表现（均 p<0.05），非抑郁组的男性 PD 患者在命名任务中的得分高于女性。抑郁和非抑郁组之间血清 BDNF 水平无性别差异。线性回归分析表明 BDNF 是抑郁男性 PD 患者语言缺陷的独立危险因素（p<0.05），而胆固醇 (CHOL) 是认知影响因素，尤其是抑郁男性 PD 患者的延迟回忆（p<0.05）。我们的研究揭示了抑郁性 PD 患者广泛的认知障碍。此外，BDNF 和 CHOL 可能有助于认知缺陷的病理机制，特别是在抑郁的男性患者中。
